The clinical value of virtual touch tissue imaging quantification technology in differential diagnosis of benign and malignant non-mass breast lesions

YU Pengli; KONG Wentao; XUE Haiyan; WANG Ying; ZHANG Yidan; GONG Li

doi:10.19732/j.cnki.2096-6210.2022.06.003

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The clinical value of virtual touch tissue imaging quantification technology in differential diagnosis of benign and malignant non-mass breast lesions

更新时间：2025-12-15

- The clinical value of virtual touch tissue imaging quantification technology in differential diagnosis of benign and malignant non-mass breast lesions
- Vol. 31, Issue 6, Pages: 575-580(2022)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.06.003
  CLC：
- Published Online：28 December 2022，
  
  Published：28 December 2022
- 稿件说明：
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于鹏丽,孔文韬,薛海燕,等. 声触诊组织成像量化技术鉴别诊断非肿块型乳腺病变良恶性的临床价值[J]. 肿瘤影像学, 2022, 31(6): 575-580 https://doi.

org/10.19732/j.cnki.2096-6210.2022.06.003
于鹏丽,孔文韬,薛海燕,等. 声触诊组织成像量化技术鉴别诊断非肿块型乳腺病变良恶性的临床价值[J]. 肿瘤影像学, 2022, 31(6): 575-580 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.06.003.

org/10.19732/j.cnki.2096-6210.2022.06.003 DOI：

摘要

目的：

探讨声触诊组织成像量化（virtual touch tissue imaging quantification，VTIQ）技术测定的剪切波速度（shear wave velocity，SWV）在诊断非肿块型乳腺病变良恶性中的应用价值。

方法：

回顾并分析2018年8月2021年7月于南京大学医学院附属鼓楼医院就诊的非肿块型乳腺病变患者203例（共207个病灶），根据穿刺活检或手术后病理学检查结果，分为良性组及恶性组。应用VTIQ技术检测病灶，比较两组间常规超声特征及SWV最大值（V

max

）、最小值（V

min

）及平均值（V

mean

）的差异。绘制受试者工作特征（receiver operating characteristic，ROC）曲线，分析VTIQ参数鉴别诊断非肿块型乳腺病变的效能。

结果：

两组间常规超声特征存在差异，良性组以片状低回声为主要表现，恶性组则以微钙化为主要表现（

＜0.001）；恶性组的血流信号Adler分级较良性组增高（

＜0.001）。恶性组病灶V

max

、V

min

及V

mean

值均明显高于良性组［（7.232.20）m/s

（3.651.27）m/s；（3.221.26）m/s

（2.200.68）m/s；（4.981.44）m/s

（2.890.86）m/s］，两组间的差异均有统计学意义（

＜0.05）。V

max

、V

min

及V

mean

鉴别非病灶良恶性的截断值分别为5.29、3.16及3.88 m/s。V

max

和V

mean

的灵敏度和特异度较高（V

max

：82.4%和90.1%；V

mean

：81.1%和89.1%），V

min

的特异度较高（88.9%），但灵敏度较低（50.1%）。

结论：

应用VTIQ技术检测非肿块型乳腺病变的SWV，对于诊断其良恶性具有一定临床价值，其中V

max

和V

mean

有较高的诊断效能。

Abstract

Objective:

To explore the clinical value of virtual touch tissue imaging quantification (VTIQ) technology in differential diagnosis of benign and malignant non-mass breast lesions.

Methods:

A retrospective analysis was performed on 203 patients with non-mass breast lesions (207 lesions in total) who were treated in Drum Tower Hospital Affiliated to Nanjing University School of Medicine from August 2018 to July 2021. According to the results of needle biopsy or surgical pathology

the patients were divided into benign and malignant group. The shear wave velocity (SWV) values were measured under the speed mode. The maximum value (V

max

)

the minimum value (V

min

) and the mean value (V

mean

) of the SWV of the lesions were measured by VTIQ. The receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic performance of V

max

min

and V

mean

in differential diagnosis of benign and malignant non-mass breast lesions.

Results:

There were differences in conventional ultrasound characteristics between the two groups. The benign group was mainly manifested by sheet hypoechoic

while the malignant group was mainly manifested by microcalcification (

＜0.001). The Adler grade of blood flow signal in the malignant group was higher than that in the benign group (

＜0.001). The V

max

min

and V

mean

values of the lesion in the malignant group were significantly higher than those in the benign group ［(7.232.20) m/s

(3.651.27) m/s; (3.221.26) m/s

(2.20 0.68) m/s; (4.98 1.44) m/s

(2.890.86) m/s］

the difference between the two groups was statistically significant (

＜0.05). The cut-off values ofV

max

min

and V

mean

in differential diagnosis of benign and malignant non-focal lesions

were 5.29

3.16 and 3.88 m/s

respectively. V

max

and V

mean

had higher sensitivity and specificity (V

max

: 82.4%

90.1%; V

mean

: 81.1%

89.1%)

and V

min

had higher specificity but lower sensitivity (88.9%

50.1%).

Conclusion:

VTIQ has important clinical value in the differential diagnosis of benign and malignant non-mass breast lesions

and V

max

and V

mean

have high diagnostic efficacy.

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Related Institution

Department of Ultrasound, Zhongshan Hospital, Fudan University

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Department of Ultrasound, Shanghai Jiao Tong University School of Medicine Affiliated Xinhua Hospital

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