Role of&nbsp; <sup>18</sup> F-FDG PET/CT and novel molecular imaging in guiding tumor immunotherapy

WANG Dongliang; XU Xiaoping; SONG Shaoli

doi:10.19732/j.cnki.2096-6210.2023.02.001

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Role of ¹⁸ F-FDG PET/CT and novel molecular imaging in guiding tumor immunotherapy

更新时间：2025-12-15

- Role of ¹⁸ F-FDG PET/CT and novel molecular imaging in guiding tumor immunotherapy
- Vol. 32, Issue 2, Pages: 101-107(2023)
- 作者机构：
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- DOI：10.19732/j.cnki.2096-6210.2023.02.001
  CLC：
- Published Online：28 April 2023，
  
  Published：28 April 2023
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王栋梁,许晓平,宋少莉. ¹⁸F-FDG PET/CT和新型分子成像在指导肿瘤免疫治疗中的作用[J]. 肿瘤影像学, 2023, 32(2): 101-107 https://doi.

org/10.19732/j.cnki.2096-6210.2023.02.001
王栋梁,许晓平,宋少莉. ¹⁸F-FDG PET/CT和新型分子成像在指导肿瘤免疫治疗中的作用[J]. 肿瘤影像学, 2023, 32(2): 101-107 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.02.001.

org/10.19732/j.cnki.2096-6210.2023.02.001 DOI：

摘要

免疫治疗是以自身免疫系统为基石的抗肿瘤反应，已经改变了许多癌症的治疗格局，但免疫检查点抑制剂（immune checkpoint inhibitor，ICI）作用机制复杂，肿瘤患者常出现延迟应答、假性进展、超进展等现象，甚至出现免疫相关不良事件。尽管新版的实体瘤免疫疗效评价标准（immune response evaluation criteria in solid tumor，iRECIST）已经应用于肿瘤免疫治疗效果评估，但基于传统影像学技术的RECIST仍存在盲区，具有一定局限性。

F-FDG正电子发射体层成像（positron emission tomography，PET）/计算机体层成像（computed tomography，CT）在评估治疗反应、预测患者预后方面具有潜在作用。新的放射性药物例如针对程序性死亡受体配体1（programmed death ligand 1，PD-L1）等免疫检查点及CD8

T细胞成像也为定义肿瘤免疫微环境提供一个独特的机会，以更好地监测患者的免疫疗效。本文回顾了免疫治疗反应评估的当前概念，癌症免疫治疗的当前临床应用和影像学需求。同时，本文讨论了FDG PET/CT在免疫治疗监测中的应用，以及应用于癌症免疫治疗成像的新兴非FDG放射性药物，旨在描述免疫治疗领域分子成像的未来趋势。

Abstract

Immunotherapy is an anti-tumor response based on the autoimmune system and has changed the treatment landscape of many cancers. However

the mechanism of immune checkpoint inhibitor (ICI) is complex

and delayed response

pseudo-progression

hyper-progression

and even immune-related adverse events often occur in tumor patients. Although the new version of immune response evaluation criteria in solid tumor (iRECIST) is applied to tumor immunotherapy

the traditional i

mage-based solid tumor efficacy evaluation criteria have some limitations and evaluation blind spots.

F-FDG positron emission tomography (PET)/computed tomography (CT) has a potential role in assessing treatment response and predicting prognosis. New radiopharmaceuticals such as targeting immune checkpoints such as programmed death ligand 1 (PD-L1) and CD8

T cell imaging also provide a unique opportunity to define the tumor immune microenvironment to better monitor immune efficacy in patients. This article reviewed current concepts of immunotherapy response assessment

current oncology applications and imaging needs of cancer immunotherapy. And the use of FDG PET/CT in immunotherapy surveillance and emerging non-FDG PET imaging radiometric tracers for cancer immunotherapy imaging were also discussed

aiming to describe future trends in molecular imaging in the field of immunotherapy.

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Related Institution

Engineering Research Center of Molecular Imaging Probes

Center for Biomedical Imaging, Fudan University

Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

College of Chemistry and Materials Sciences, Shanghai Normal University

Department of Radiology, The Children's Hospital, Zhejiang University School of Medicine

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Role of 18 F-FDG PET/CT and novel molecular imaging in guiding tumor immunotherapy

DOI：10.19732/j.cnki.2096-6210.2023.02.001

摘要

Abstract

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Role of ¹⁸ F-FDG PET/CT and novel molecular imaging in guiding tumor immunotherapy