Nuclear medicine and molecular imaging of T cell effector function: toward precision immunotherapy of cancer

ZHOU Haoyi; LIU Zhaofei

doi:10.19732/j.cnki.2096-6210.2023.02.002

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Nuclear medicine and molecular imaging of T cell effector function: toward precision immunotherapy of cancer

更新时间：2025-12-15

- Nuclear medicine and molecular imaging of T cell effector function: toward precision immunotherapy of cancer
- Vol. 32, Issue 2, Pages: 108-113(2023)
- 作者机构：
  
  1. 北京大学基础医学院放射医学系医学同位素研究中心,北京,100191
  2. 北京大学肿瘤医院核医学科,北京,100142
  3. 北京大学第三医院核医学科,北京,100191
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2023.02.002
  CLC：
- Published Online：28 April 2023，
  
  Published：28 April 2023
- 稿件说明：
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周昊毅,刘昭飞. T细胞效应功能核医学显像：迈向精准肿瘤免疫治疗[J]. 肿瘤影像学, 2023, 32(2): 108-113 https://doi.

org/10.19732/j.cnki.2096-6210.2023.02.002
周昊毅,刘昭飞. T细胞效应功能核医学显像：迈向精准肿瘤免疫治疗[J]. 肿瘤影像学, 2023, 32(2): 108-113 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.02.002.

org/10.19732/j.cnki.2096-6210.2023.02.002 DOI：

摘要

免疫治疗在肿瘤治疗领域取得了突破性的进展。然而，单一免疫疗法的患者响应率低等不足仍然限制着其广泛应用。如何在早期精确预测肿瘤患者对免疫治疗的响应仍是目前临床所面临的挑战。因此，迫切需要一种可靠的在体可视化方法，能够准确反映肿瘤在治疗过程中的关键免疫细胞/分子信息的变化，进而预测免疫治疗效果及优化免疫治疗策略。核医学分子影像能够在体、无创、定量可视化关键免疫相关生物标志物，为解析肿瘤免疫微环境提供了有效的技术手段。本文对目前已应用于肿瘤免疫治疗效果监测的核医学分子影像学研究动态与进展进行了简要述评。

Abstract

Immunotherapy has achieved remarkable clinical success in the field of cancer therapy. However

the relatively small fraction of patients who benefit from immunotherapy limits its widespread applications. Accurately identifying patients who would respond to immunotherapy at early stages remains clinically challenging. Therefore

an in vivo method that can noninvasivelycapture information about immune cell/molecule function during immunotherapy and assist in the optimization of immunotherapy strategies is highly desirable. Nuclear medicine and molecular imaging provide a robust tool for the annotation of cancer immune microenvironment through noninvasive visualization of key immune-related biomarkers in vivo in a quantitative manner. This article concisely reviewed the current progresses in nuclear medicine and molecular imaging-guided treatment monitoring for cancer immunotherapy.

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