Application and progress of PSMA probes in the diagnosis and treatment of prostate cancer

MO Yiwen; LI Ruping; FAN Wei

doi:10.19732/j.cnki.2096-6210.2023.03.001

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Application and progress of PSMA probes in the diagnosis and treatment of prostate cancer

更新时间：2025-12-15

- Application and progress of PSMA probes in the diagnosis and treatment of prostate cancer
- Vol. 32, Issue 3, Pages: 205-212(2023)
- 作者机构：
  
  1. 中山大学肿瘤防治中心，中山大学肿瘤研究所，华南肿瘤学国家重点实验室，肿瘤医学协同创新中心核医学科,广东,广州,510060
  2. 河南省肿瘤医院核医学科,河南,郑州,450003
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2023.03.001
  CLC：
- Published Online：28 June 2023，
  
  Published：28 June 2023
- 稿件说明：
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莫奕文,李汝平,樊卫. PSMA分子靶向探针在前列腺癌诊疗中的应用及研究进展[J]. 肿瘤影像学, 2023, 32(3): 205-212 https://doi.

org/10.19732/j.cnki.2096-6210.2023.03.001
莫奕文,李汝平,樊卫. PSMA分子靶向探针在前列腺癌诊疗中的应用及研究进展[J]. 肿瘤影像学, 2023, 32(3): 205-212 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.03.001.

org/10.19732/j.cnki.2096-6210.2023.03.001 DOI：

摘要

前列腺癌（prostate cancer，PCa）是威胁中老年男性生命健康常见的恶性肿瘤之一。前列腺特异性膜抗原（prostate-specific membrane antigen

PSMA）是表达于前列腺上皮细胞的Ⅱ型跨膜糖蛋白。与非病变前列腺组织相比，PCa组织中PSMA表达可上升100~1 000倍。近年来，以PSMA作为分子显像和治疗靶点受到广泛关注，其在PCa分期、再分期、治疗和疗效评价中具有独特优势和重要价值。本文将围绕PSMA分子靶向探针在前列腺癌分子显像及治疗中的最新研究进展作简要述评，以期更好地服务于临床。

Abstract

Prostate cancer (PCa) is one of the common malignant tumors threatening the life and health of middle-aged and elderly men. Prostate-specific membrane antigen (PSMA) is a type Ⅱ transmembrane glycoprotein expressed in prostate epithelial cells. Compared with non-diseased prostate tissues

the expression of PSMA in prostate cancer was increased by 100-1 000 times.In recent years

PSMA has been attracted much attention as a target for prostate cancer imaging and treatment. It plays a unique and important role in prostate cancer staging

restaging

treatment and efficacy evaluation. Based on this

this paper briefly reviewed the latest progress of the application of PSMA molecular targeting probe in PCa imaging and treatment of PCa

in order to better serve the clinic.

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Related Institution

Department of Nuclear Medicine, Affilitated Hospital of Southwest Medical University

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Department of Radiology, Chengdu Seventh People’s Hospital, Affilitated Cancer Hospital of Chengdu Medical College

Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Center for Biomedical Imaging, Fudan University, Shanghai Engineering Research Center of Molecular Imaging Probes

Department of Pharmacy, Wuxi Maternal and Child Health Care Hospital

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