The treatment outcome and prognosis of CT-guided radiofrequency ablation for elderly patients with non-small cell lung cancer who cannot be treated with surgery

YU Jianxun; WEN Ning; LI Xuehua; LI Xuefei; LI Weipin

doi:10.19732/j.cnki.2096-6210.2023.03.009

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The treatment outcome and prognosis of CT-guided radiofrequency ablation for elderly patients with non-small cell lung cancer who cannot be treated with surgery

更新时间：2025-12-15

- The treatment outcome and prognosis of CT-guided radiofrequency ablation for elderly patients with non-small cell lung cancer who cannot be treated with surgery
- Vol. 32, Issue 3, Pages: 269-274(2023)
- 作者机构：
  
  1. 南宁市红十字会医院内 2 科,广西,南宁,530012
  2. 广西医科大学第二附属医院移植医学中心,广西,南宁,530007
  3. 南宁市红十字会医院护理部,广西,南宁,530012
  4. 南宁市红十字会医院放射科,广西,南宁,530012
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2023.03.009
  CLC：
- Published Online：28 June 2023，
  
  Published：28 June 2023
- 稿件说明：
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玉建勋,文宁,黎雪华,等. 探讨CT引导下射频消融治疗无法手术治疗的老年非小细胞肺癌患者的疗效及预后[J]. 肿瘤影像学, 2023, 32(3): 269-274 https://doi.

org/10.19732/j.cnki.2096-6210.2023.03.009
玉建勋,文宁,黎雪华,等. 探讨CT引导下射频消融治疗无法手术治疗的老年非小细胞肺癌患者的疗效及预后[J]. 肿瘤影像学, 2023, 32(3): 269-274 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.03.009.

org/10.19732/j.cnki.2096-6210.2023.03.009 DOI：

摘要

目的：

探讨计算机体层成像（computed tomography，CT）引导下射频消融治疗无法手术治疗的老年非小细胞肺癌（non-small cell lung cancer，NSCLC）患者的疗效及预后。

方法：

选取2010年1月2014年1月南宁市红十字会医院收治的191例无法手术治疗的老年NSCLC患者作为研究对象。观察射频消融治疗老年NSCLC的疗效、安全性及预后情况。

结果：

191例老年NSCLC患者CT引导下射频消融治疗手术均取得成功，术后总有效率为47.12%。191例患者治疗期间并发症发生率为49.74%，无死亡患者。191例NSCLC患者1、3、5年总生存率为94.76%、70.68%、37.70%；1、3、5年无瘤生存率为84.82%、62.83%、28.27%。Cox单因素及多因素分析显示肿瘤直径、TNM分期、淋巴结转移、分子靶向治疗及淋巴管血管侵犯与老年NSCLC患者总生存期密切相关，肿瘤直径、淋巴结转移及淋巴管血管侵犯与老年NSCLC患者无瘤生存期密切相关。

结论：

CT引导下射频消融对无法手术治疗的老年NSCLC患者有一定疗效，安全性尚可。肿瘤直径、TNM分期、淋巴结转移、分子靶向治疗及淋巴管血管侵犯可能影响接受射频消融治疗的患者预后。

Abstract

Objective:

To investigate the efficacy and prognosis of computed tomography (CT)-guided radiofrequency ablation for elderly patients with non-small cell lung cancer (NSCLC) who cannot be treated with surgery.

Methods:

From January 2010 to January 2014

191 elderly patients with NSCLC who could not be treated surgically were selected as the study subjects. To observe the eff

icacy

safety and prognosis of radiofrequency ablation in the treatment of elderly NSCLC.

Results:

191 elderly patients with NSCLC underwent CT-guided radiofrequency ablation successfully. The total effective rate was 47.12%. The incidence of complications was 49.74% in 191 patients

and there was no death. The 1

5-year overall survival rates of 191 patients with NSCLC were 94.76%

70.68% and 37.70%

while the 1

3 and 5-year disease-free survival rates were 84.82%

62.83% and 28.27%. Cox univariate and multivariate analysis showed that tumor diameter

TNM stage

lymph node metastasis

molecular targeted therapy and lymphovascular invasion (LVI) were closely related to the overall survival of elderly patients with NSCLC. Tumor diameter

lymph node metastasis and LVI were closely related to the disease-free survival of elderly patients with NSCLC.

Conclusion:

CT- guided radiofrequency ablation might have a certain curative effect on inoperable elderly patients with NSCLC

and the safety isacceptable. Tumor diameter

TNM stage

lymph node metastasis

molecular targeted therapy

and LVI may affect the prognosis of patients receiving radiofrequency ablation.

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