The value of fast spin-echo diffusion-weighted imaging in the evaluation of focus activity in children with retinoblastoma

LI Lin; LI Fangyuan; ZHAO Jianshe; CUI Ruodi; SUN Zhiqun

doi:10.19732/j.cnki.2096-6210.2023.03.010

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The value of fast spin-echo diffusion-weighted imaging in the evaluation of focus activity in children with retinoblastoma

更新时间：2025-12-15

- The value of fast spin-echo diffusion-weighted imaging in the evaluation of focus activity in children with retinoblastoma
- Vol. 32, Issue 3, Pages: 275-280(2023)
- 作者机构：
  
  1. 山东大学附属儿童医院（济南市儿童医院）医学影像中心,山东,济南,250022
  2. 济南南郊医院影像科,山东,济南,250003
  3. 山东省潍坊市人民医院新生儿科,山东,潍坊,261041
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2023.03.010
  CLC：
- Published Online：28 June 2023，
  
  Published：28 June 2023
- 稿件说明：
移动端阅览
李林,李方元,赵建设,等. 快速自旋回波弥散加权成像在视网膜母细胞瘤患儿病灶活动性评估中的价值[J]. 肿瘤影像学, 2023, 32(3): 275-280 https://doi.

org/10.19732/j.cnki.2096-6210.2023.03.010
李林,李方元,赵建设,等. 快速自旋回波弥散加权成像在视网膜母细胞瘤患儿病灶活动性评估中的价值[J]. 肿瘤影像学, 2023, 32(3): 275-280 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.03.010.

org/10.19732/j.cnki.2096-6210.2023.03.010 DOI：

摘要

目的：

分析快速自旋回波弥散加权成像（fast spin-echo diffusion-weighted imaging，TSE-DWI）在评估单眼发病眼内期视网膜母细胞瘤（retinoblastoma，RB）患儿病灶活动性中的价值。

方法：

收集2014年5月2018年7月于山东大学附属儿童医院临床诊治的180例单眼发病眼内期RB患儿及53例社区健康志愿者（对照组）的磁共振成像（magnetic resonance imaging，MRI）资料及相关临床资料。所有患儿均行MRI常规序列、TSE-DWI及动态对比增强MRI（dynamic contrast-enhanced MRI，DCE-MRI）检查，患儿分别于治疗前、后及稳定期各检查1次，对照组只进行1次扫描。对比患儿眼球内病灶活动期、稳定期及对照组表观弥散系数（apparent diffusion coefficient，ADC）及信号强度增强率（signal strength enhancement ratio，△SI）的变化及两者在评估病灶是否具有活动性中的效能。

结果：

治疗前病灶TSE-DWI呈高信号，ADC图呈低信号，增强扫描呈不同程度强化；治疗后病灶体积缩小，DWI信号减低，ADC图信号增高，增强后不强化或轻度强化。病灶活动期、稳定期及对照组ADC与△SI差异均有统计学意义（

＜0.001）。△SI=1.14%时，鉴别病灶是否具有活动性的灵敏度、特异度及准确度分别为75.91%、82.31%及87.56%，ADC=1.1710

-3

/mm

时，鉴别病灶是否具有活动性的灵敏度、特异度及准确度分别为95.72%、87.23%及93.76%。两者鉴别病灶是否具有活动性的能效相似。

结论：

在评估病灶是否具有活动性方面，TSE-DWI与DCE-MRI价值相似，但TSE-DWI更具优势。

Abstract

Objective:

To analyze the value of fast spin-echo diffusion-weighted imaging (TSE-DWI) in the evaluation of focal activity in children with intraocular simul

taneous unilateral retinoblastoma (RB).

Methods:

The magnetic resonance imaging (MRI) data and relevant clinical data of 180 children with intraocular simultaneous unilateral RB who were clinically diagnosed and treated in the Affiliated Childrens Hospital of Shandong University from May 2014 to July 2018 and 53 communal healthy volunteers (control group) were collected. All cases were performed MRI routine sequence

TSE-DWI and dynamic contrast-enhanced MRI (DCE-MRI)

and were examined once before treatment

after treatment and in stable period

the control group was scanned once. The changes of apparent diffusion coefficient (ADC) and signal intensity enhancement ratio (△SI) in the active and stable stage of the intraocular lesions and the control group were compared

and their effectiveness in evaluating whether the lesions were active or no.

Results:

The TSE-DWI of lesions before treatment showed high signal

the corresponding ADC image showed low signal

and the enhanced scanning showed enhancement with different degrees. After treatment

the lesion volume decreased

the DWI signal decreased

the ADC image signal increased，no or medium enhancement. The differences of ADC and △SI in active phase

stable phase and control group were statistically significant (

＜0.001). When △SI=1.14%

the sensitivity

specificity and accuracy of identifying whether the lesion was active were 75.91%

82.31%

and 87.56% respectively. When ADC=1.1710

-3

/mm

the sensitivity

specificity and accuracy of identifying whether the lesion was active were 95.72%

87.23%and 93.76% respectively. The energy efficiency of the two method to distinguish whether the lesion was active similarly.

Conclusion:

In assessing whether the lesion is active or not

the value of TSE-DWI was similar to the DCE-MRI

but TSE-DWI has the advantage.

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