The value of quantitative parameters of amide proton transfer imaging in predicting bone metastasis of prostate

YANG Li; TAN Yuchuan; DAN Hanli; YANG Lu

doi:10.19732/j.cnki.2096-6210.2023.04.006

您当前的位置：

首页 >

文章列表页 >

The value of quantitative parameters of amide proton transfer imaging in predicting bone metastasis of prostate

更新时间：2025-12-15

- The value of quantitative parameters of amide proton transfer imaging in predicting bone metastasis of prostate
- Vol. 32, Issue 4, Pages: 347-352(2023)
- 作者机构：
  
  1. 重庆大学附属肿瘤医院影像科,重庆,400030
  2. 重庆大学生物工程学院生物与医药专业,重庆,400044
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2023.04.006
  CLC：
- Published Online：13 September 2023，
  
  Published：13 September 2023
- 稿件说明：
移动端阅览
杨　莉,谭钰川,但汉丽,杨　露. 氨基质子转移成像定量参数预测前列腺癌骨转移的价值肿瘤影像学, 2023, 32(4): 347-352 https://doi.

org/10.19732/j.cnki.2096-6210.2023.04.006
杨　莉,谭钰川,但汉丽,杨　露. 氨基质子转移成像定量参数预测前列腺癌骨转移的价值肿瘤影像学, 2023, 32(4): 347-352 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.04.006.

org/10.19732/j.cnki.2096-6210.2023.04.006 DOI：

摘要

目的：

探讨氨基质子转移成像（amide proton transfer imaging，APT）定量参数对初诊前列腺癌患者骨转移风险的预测价值。

方法：

回顾并分析2019年7月—2022年3月于重庆大学附属肿瘤医院行APT检查的42例未经治疗的初诊前列腺癌患者的影像学及临床资料，患者均经前列腺穿刺活检或手术后病理学检查确诊，其中无骨转移组27例，骨转移组15例。采用独立样本

检验或秩和检验分析各参数在预测前列腺癌骨转移风险方面的差异。通过logistic回归模型测算参数联合应用的预测概率，并绘制受试者工作特征（receiver operating characteristic，ROC）曲线进行分析。

结果：

年龄、睾酮、黄体生成素、卵泡刺激素、泌乳素、雌二醇、前列腺影像报告和数据系统（Prostate Imaging Reporting And Data System，PI-RADS）评分在两组之间的差异无统计学意义（

＞0.05），而总前列腺特异性抗原（prostate-specific antigen，PSA）、APT平均值（APTw）、表观弥散系数（apparent diffusion coefficient，ADC）、前列腺病理学Gleason评分及血清碱性磷酸酶在预测前列腺癌骨转移风险方面差异有统计学意义（

＜0.05），前列腺癌骨转移阳性组的APTw（2.989±1.018）高于阴性组（2.273±1.015）。ROC曲线分析结果显示，APTw独立预测前列腺癌骨转移风险的特异度较高（88.46），所有参数联合应用的预测能力最佳（曲线下面积为0.866）。

结论：

APT定量参数与前列腺癌骨转移密切相关，对初诊前列腺癌患者转移风险有较好的预测价值。

Abstract

Objective:

To investigate the predictive value of quantitative parameters of amide proton transfer imaging (APT) on the risk of bone metastasis in newly diagnosed prostate cancer patients.

Methods:

Retrospecti

ve analysis was conducted on the imaging and clinical data of 42 untreated patients with prostate cancer diagnosed by prostate tissue puncture or surgery pathology from July 2019 to March 2022 who underwent APT examination in Chongqing University Cancer Hospital. There were 27 cases in non-bone metastasis group and 15 cases in bone metastasis group. Independent sample t test or rank sum test were used to analyze the difference of parameters in predicting the risk of prostate cancer bone metastasis. The prediction probability of joint application of parameters was calculated through the modeling of logistic regression model

and the receiver operating characteristic (ROC) curve is drawn for analysis.

Results:

The results showed that there was no significant difference between the two groups in age testosterone

luteinizing hormone

follicle stimulating hormone

prolactin

estradiol

and Prostate Imaging Reporting And Data System (PI- RADS) score (

＞0.05); there were statistically significant differences between total prostate-specific antigen (PSA)

APTw

apparent diffusion coefficient (ADC)

Gleason score of prostate puncture and serum alkaline phosphatase in predicting the risk of bone metastasis of prostate cancer (

＜0.05). The ROC curve analysis showed that APTw had a high specificity (88.46) in independently predicting the risk of bone metastasis of prostate cancer

and the combination of all parameters had the best predictive ability (areaunder curve was 0.866).

Conclusion:

Quantitative parameters of APT are closely related to bone metastasis of prostate cancer

and can be an effective risk factor for predicting bone metastasis of prostate cancer.

关键词

Keywords

references

Views

421

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

A comparative study of ⁶⁸Ga-TBM-001 PET/CT and ^99mTc-MDP bone scintigraphy in the diagnosis of bone metastases of prostate cancer

The value of transrectal ultrasound fusion with mpMRI navigation combined with elastography-guided targeted prostate biopsy

A study on the quality of T2-weighted FatSat images of prostate and its diagnostic value based on deep learning reconstruction technology

Diagnostic efficiency and inter-observer agreement among readers with variable experience of PI-RR system: using whole-mount histology after androgen deprivation therapy as reference

Application progress of functional magnetic resonance imaging in radiotherapy for prostate cancer

Related Author

Dan SU

Taoming DU

Yue CHEN

Anyu LI

Zheng ZHU

Qi MA

Shijie DONG

Xiaoxin HU

Related Institution

Department of Radiology, Chengdu Seventh People’s Hospital, Affilitated Cancer Hospital of Chengdu Medical College

Department of Nuclear Medicine, Chengdu Seventh People’s Hospital, Affilitated Cancer Hospital of Chengdu Medical College

Department of Nuclear Medicine, Affilitated Hospital of Southwest Medical University

Department of Ultrasound, Soochow University Affiliated Taicang First People's Hospital

Department of Ultrasound, The Second Affiliated Hospital of Soochow University

AI问答

⁰