Clinical value of&nbsp; <sup>99m</sup> Tc-MIBI imaging in&nbsp;<sup> 131</sup> I treatment of lymph node metastases of differentiated thyroid cancer

SHENG Shiwei; WANG Yang; CHEN Libo; LU Hankui

doi:10.19732/j.cnki.2096-6210.2023.04.009

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Clinical value of ^99m Tc-MIBI imaging in ¹³¹ I treatment of lymph node metastases of differentiated thyroid cancer

更新时间：2025-12-15

- Clinical value of ^99m Tc-MIBI imaging in ¹³¹ I treatment of lymph node metastases of differentiated thyroid cancer
- Vol. 32, Issue 4, Pages: 367-372(2023)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2023.04.009
  CLC：
- Published Online：13 September 2023，
  
  Published：13 September 2023
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盛矢薇,王阳,陈立波,等. ^99m Tc-MIBI显像在 ¹³¹ I治疗分化型甲状腺癌淋巴结转移灶中的临床价值[J]. 肿瘤影像学, 2023, 32(4): 367-372 https://doi.

org/10.19732/j.cnki.2096-6210.2023.04.009
盛矢薇,王阳,陈立波,等. ^99m Tc-MIBI显像在 ¹³¹ I治疗分化型甲状腺癌淋巴结转移灶中的临床价值[J]. 肿瘤影像学, 2023, 32(4): 367-372 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.04.009.

org/10.19732/j.cnki.2096-6210.2023.04.009 DOI：

摘要

目的：

探讨

99m

Tc-甲氧基异丁基异腈（methoxyisobutylisonitrile，MIBI）显像辅助诊断分化型甲状腺癌（differentiated thyroid carcinoma，DTC）淋巴结转移的价值。

方法：

纳入临床确诊DTC淋巴结转移患者78例。患者在接受放射性碘131（iodine 131，

131

I）治疗前均进行颈部超声、

99m

Tc-MIBI颈胸部显像（多时相）、计算机体层成像（computed tomography，CT）和/或

F-FDG正电子发射体层成像（positron emission tomography，PET）/CT。

131

I治疗后96 h进行

131

I全身扫描和

131

I单光子发射计算机体层成像（single-photon emission computed tomography，SPECT）/CT颈胸部显像。

131

I治疗前后动态检测血清甲状腺球蛋白（thyroglobulin，Tg）和抗甲状腺球蛋白抗体（antithyroglobulin antibody，TgAb）水平变化及其他相关检查。

131

I治疗后随访期为1~2年。

结果：

32例DTC淋巴结转移在

99m

Tc-MIBI显像上为阳性，诊断灵敏度为41.0%（32/78），显著低于

131

I治疗后扫描显示的淋巴结阳性率64.1%（50/78）（

＜0.01）。而在

131

I治疗后扫描为阴性中，

99m

Tc-MIBI显像为阳性者为19例，阳性率67.9%（19/28）。

131

I治疗后随访期内42例患者呈临床治愈或病情好转，其中35例

99m

Tc-MIBI显像为阴性（83.3%）；19例病情稳定，

99m

Tc-MIBI显像阴性8例（42.1%）；另17例病情呈进展趋势，

99m

Tc-MIBI显像阴性者仅3例（17.6%），组间差异有统计学意义（

＜0.01）。

结论：

99m

Tc-MIBI显像可有助于提高DTC淋巴结转移的阳性检出率，并可辅助预测

131

I治疗后的转归趋势。

Abstract

Objective:

To investigate the clinical value of

99m

Tc-methoxyisobutylisonitrile (MIBI) imaging in the

131

I treatment of lymph node metastases from differentiated thyroid carcinoma (DTC).

Methods:

A total of 78 patients with DTC lymph node metastasis were selected. All patients underwent neck ultrasound

99m

Tc-MIBI neck and chest imaging (multi-phases)

chest computed tomography (CT) scan and/or

F-FDG positron emission tomography (PET)/CT whole body imaging before

131

I treatment.

131

I whole body scan and

131

I single-photon emission computed tomography (SPECT)/CT neck and chest scan were performed 96 hours after

131

I treatment. Serum thyroglobulin (Tg) and thyroglobulin antibody (TgAb) levels were dynamically detected before and after

131

I treatment

as well as other related examinations. The follow-up period after

131

I treatment was 1-2 years.

Results:

Among those patients with DTC lymph node metastases

32 patients were found with positive lesions on

99m

Tc-MIBI imaging. The diagnostic sensitivity of

99m

Tc-MIBI imaging for DTC lymph node metastases was 41.0% (32/78)

which was significantly lower than that of

131

I post-therapeutical scan (64.1%

50/78) (

＜0.01). Among those patients with negative

131

I post-therapeutical scan for lymph node metastases

19 were positive on

99m

Tc-MIBI imaging

with a positive rate of 67.9% (19/28). During the follow-up period

42 patients were clinically cured or their condition improved

of which 35 were negative on

99m

Tc-MIBI imaging (83.3%). 19 cases were stable

of which 8 cases (42.1%) were negative on

99m

Tc-MIBI imaging (42.1%). The other 17 cases were clinically

found on progressive trend

of which only 3 cases were negative in on

99m

Tc-MIBI imaging (17.6%). The difference between the sub-groups was muchsignificant (

＜0.01).

Conclusion:

99m

Tc-MIBI imaging could help to improve the diagnostic efficacy of DTC lymph node metastases and enhance the prediction of the therapeutic effects after

131

I treatment.

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Clinical value of 99m Tc-MIBI imaging in 131 I treatment of lymph node metastases of differentiated thyroid cancer

DOI：10.19732/j.cnki.2096-6210.2023.04.009

摘要

Abstract

关键词

Keywords

references

Clinical value of ^99m Tc-MIBI imaging in ¹³¹ I treatment of lymph node metastases of differentiated thyroid cancer