Ultrasonographic features of solid papillary carcinoma of the breast and its pathologic correlation

LI Yujia; HUANG Beijian; XIA Hansheng; LIU Limin; PENG Lichun

doi:10.19732/j.cnki.2096-6210.2023.06.003

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Ultrasonographic features of solid papillary carcinoma of the breast and its pathologic correlation

更新时间：2025-12-15

- Ultrasonographic features of solid papillary carcinoma of the breast and its pathologic correlation
- Vol. 32, Issue 6, Pages: 500-505(2023)
- 作者机构：
  
  复旦大学附属中山医院超声科,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2023.06.003
  CLC：
- Published Online：28 December 2023，
  
  Published：28 December 2023
- 稿件说明：
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李玉佳,黄备建,夏罕生,等. 乳腺实性乳头状癌的超声表现及其病理学相关性研究[J]. 肿瘤影像学, 2023, 32(6): 500-505 https://doi.

org/10.19732/j.cnki.2096-6210.2023.06.003
李玉佳,黄备建,夏罕生,等. 乳腺实性乳头状癌的超声表现及其病理学相关性研究[J]. 肿瘤影像学, 2023, 32(6): 500-505 https://doi. DOI： 10.19732/j.cnki.2096-6210.2023.06.003.

org/10.19732/j.cnki.2096-6210.2023.06.003 DOI：

摘要

目的：

探讨乳腺实性乳头状癌（solid papillary carcinoma of the breast，SPC）的灰阶超声、彩色多普勒超声及超声弹性成像表现，并探讨SPC的超声表现与其病理学检查结果的相关性。

方法：

分析71例经术后病理学检查证实的SPC患者的临床资料，共包括75个SPC病灶的灰阶超声、彩色多普勒超声表现和35个SPC病灶的超声弹性成像表现。比较不同病理学亚型SPC的超声表现及与病理学检查结果的相关性。

结果：

SPC的超声表现大多为单发的低回声实性肿块，呈水平生长，形态不规则，边缘不光整，后方回声增强或不变，可伴有导管扩张及钙化，Adler血流分级Ⅱ~Ⅲ级，阻力指数（resistance index，RI）为0.62~0.84。几乎不伴有腋窝淋巴结转移。75个SPC病灶病理学分子分型均为Luminal A型。Ki-67增殖指数在42个原位SPC病灶中均＜20%，在15个浸润性SPC中为20%~60%，两者差异有统计学意义（

=0.000）。

结论：

SPC超声表现具有一定特征性，结合灰阶、彩色多普勒超声及超声弹性成像可提高其诊断准确度，但超声无法鉴别原位SPC及浸润性SPC，Ki-67增殖指数与SPC是否浸润有关。

Abstract

Objective:

To investigate the gray scale ultrasound

color Doppler ultrasound and ultrasonic elastography findings of solid papillary carcinoma of the breast (SPC)

and to explore the correlation between the ultrasound findings of SPC and its pathology.

Methods:

The clinical data of 71 patients with SPC confirmed by surgery and pathology were analyzed

including gray scale and color Doppler ultrasound findings of 75 SPC lesions and ultrasonic elastogra

phy findings of 35 SPC lesions. To compare the ultrasonographic features and pathological correlation of different pathological subtypes of SPC.

Results:

Most of the sonographic manifestations of SPC were solitary hypoechoic solid masses with parallel origin

irregular shape

ill-defined margin

enhanced or unchanged posterior echo

and could be accompanied by duct dilation and calcification. Adler blood flow grade was Ⅱ-Ⅲ

and the resistance index (RI) range was 0.62-0.84. There was almost no axillary lymph node metastasis. The pathological molecular subtype of 75 SPC lesions was Luminal A type. Ki-67 proliferation index was ＜20% in 42 in situ SPC lesions

and the expression range was 20%-60% in 15 invasive SPC lesions

with a statistically significant difference between the subtypes (

=0.000).

Conclusion:

The ultrasound manifestations of SPC has certain characteristics. Combining gray scale

color Doppler

and ultrasonic elastography can improve the diagnostic accuracy. Ultrasound cannot distinguish between in situ SPC and invasive SPC. The Ki-67 proliferation index is related to whether SPC is infiltrating.

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Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

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Department of Ultrasound, Shanghai Pudong New Area People's Hospital

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