Advances and prospects of PET/MRI of brain tumors

GUAN Yihui

doi:10.19732/j.cnki.2096-6210.2024.02.002

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Advances and prospects of PET/MRI of brain tumors

更新时间：2025-12-15

- Advances and prospects of PET/MRI of brain tumors
- Vol. 33, Issue 2, Pages: 108-114(2024)
- 作者机构：
- 作者简介：
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- DOI：10.19732/j.cnki.2096-6210.2024.02.002
  CLC：
- Published Online：10 May 2024，
  
  Published：10 May 2024
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管一晖. 脑肿瘤的PET/MRI研究进展及展望[J]. 肿瘤影像学, 2024, 33(2): 108-114 https://doi.

org/10.19732/j.cnki.2096-6210.2024.02.002
管一晖. 脑肿瘤的PET/MRI研究进展及展望[J]. 肿瘤影像学, 2024, 33(2): 108-114 https://doi. DOI： 10.19732/j.cnki.2096-6210.2024.02.002.

org/10.19732/j.cnki.2096-6210.2024.02.002 DOI：

摘要

正电子发射体层成像（positron emission tomography，PET）与氨基酸示踪剂所提供的脑肿瘤（尤其是胶质瘤）的生物学特征已超越了传统结构磁共振成像（magnetic resonance imaging，MRI），可用于脑肿瘤初始诊断、肿瘤边缘的描绘、手术和放射治疗的计划制订、残留肿瘤的评估及治疗后反应的评估。PET/MRI一体化成像允许在一次检查中同时获取PET和功能MRI序列多个参数，减少扫描时间，氨基酸PET与功能MRI［弥散加权成像（diffusion-weighted imaging，DWI）或灌注加权成像（perfusion weighted imaging，PWI）］空间分布一致性虽然存在争议，但毋庸置疑的是，多模态检查模式对脑胶质瘤的功能学评估提供了重要的互补信息。本述评旨在简述脑肿瘤各种氨基酸示踪剂，以及对氨基酸PET/MRI在胶质瘤治疗中的临床应用的实际理解，另外还概述了新型放射性示踪剂转化进展，展望氨基酸PET/MRI放射组学、机器学习和成本效益方面的未来应用前景。

Abstract

Positron emission tomography (PET) and amino acid tracers provide a biological characterization of brain tumors (especially gliomas) beyond conventional structural magnetic resonance imaging (MRI)

and can be used for initial diagnosis of brain tumors

mapping of tumor margins

planning of surgery and radiation therapy

evaluation of residual tumors

and evaluation of post-treatment response. Integrated PET/MRI allows simultaneous acquisition of PET and multiple parameters including functionalMRI sequences in a single examination

reducing scan time. While the consistency of the spatial distribution of amino acid PET with functional MRI ［diffusion-weighted imaging (DWI) or perfusion weighted imaging (PWI)］ is controversial. There is no doubt that the multimodal examination model provides important complementary information for the functional assessment of brain gliomas. This review aimed to provide a concise overview of the various amino acid tracers in brain tumors

as well as a practical understanding of the clinical applications of amino acid PET/MRI in the treatment of glioma

in addition to an overview of the progress in the transformation of novel radioactive tracers

the prospects for future applications in amino acid PET/MRI radiomics and machine learning and cost-effectiveness.

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