Comparison of image quality and clinical application value of <sup>68</sup> Ga-FAPI-04 PET/CT in multi-time point scanning of abdominal tumors

ZHANG Zeyu; CUI Bin; WANG Jianhua; WANG Shengli; ZHANG Yingying; LIANG Siyu; CHENG Chao; ZUO Changjing

doi:10.19732/j.cnki.2096-6210.2024.05.005

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Comparison of image quality and clinical application value of ⁶⁸ Ga-FAPI-04 PET/CT in multi-time point scanning of abdominal tumors

更新时间：2025-12-15

- Comparison of image quality and clinical application value of ⁶⁸ Ga-FAPI-04 PET/CT in multi-time point scanning of abdominal tumors
- Vol. 33, Issue 5, Pages: 493-500(2024)
- 作者机构：
  
  1. 海军军医大学第一附属医院上海长海医院核医学科,上海,200433
  2. 厦门大学附属第一医院放射科,福建,厦门,361003
  3. 中国科学院上海应用物理研究所,上海,201800
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2024.05.005
  CLC：
- Published Online：07 November 2024，
  
  Published：07 November 2024
- 稿件说明：
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章泽宇,崔斌,汪建华,等. ⁶⁸ Ga-FAPI-04 PET/CT在腹部肿瘤多时间点扫描中的图像质量对比及其临床应用价值研究[J]. 肿瘤影像学, 2024, 33(5): 493-500 https://doi.

org/10.19732/j.cnki.2096-6210.2024.05.005
章泽宇,崔斌,汪建华,等. ⁶⁸ Ga-FAPI-04 PET/CT在腹部肿瘤多时间点扫描中的图像质量对比及其临床应用价值研究[J]. 肿瘤影像学, 2024, 33(5): 493-500 https://doi. DOI： 10.19732/j.cnki.2096-6210.2024.05.005.

org/10.19732/j.cnki.2096-6210.2024.05.005 DOI：

摘要

目的：

本研究旨在探讨

Ga-成纤维细胞活化蛋白抑制剂（fibroblast activation protein inhibitor，FAPI）-04正电子发射体层成像（positron emission tomography，PET）/计算机体层成像（computed tomography，CT）显像的最佳扫描时间点，并评估肿瘤与阻塞性炎症中

Ga-FAPI-04药代动力学的差异。

方法：

回顾并分析2021年1—11月因腹部肿瘤在海军军医大学第一附属医院接受

Ga-FAPI-04 PET/CT显像的患者临床资料。利用Kruskal-Wallis H秩和检验比较各时间点肿瘤灶的最大标准摄取值（maximum standard uptake value，SUV

max

）、肿瘤背景比值（tumor-to-background ratio，TBR）和图像信噪比（signal to noise ratio，SNR）；通过Mann-Whitney

检验对肿瘤及阻塞性炎症的滞留指数（retention index，RI）进行差异分析。

结果：

本研究共纳入31例患者，在15 min、1 h和2 h肿瘤灶的SUV

max

分别为8.52（4.18~18.4）、8.59（4.69~13.8）和7.64（3.22~21.0），对应的TBR为4.22（1.87~17.76）、4.67（2.20~29.05）和4.30（2.48~35.20）。尽管1 h的SUV

max

和TBR值高于其他时间点，但差异无统计学意义（

＞0.05）。15 min、1 h和2 h的SNR分别为6.41（2.45~8.24）、5.0（1.68~5.57）和3.02（1.39~6.97），差异有统计学意义（

=51.691，

＜0.001），其中15 min的SNR最高。此外，15 min与1 h间肿瘤灶的RI显著高于阻塞性炎症（-0.195~0.415

-0.422~0.115），差异亦有统计学意义（

=0.018）。

结论：

注射

Ga-FAPI-04后15 mi

n的图像SNR最高，可作为临床常规扫描时间点。此外，15 min与1 h的RI可有效地用于区分肿瘤与阻塞性炎症。

Abstract

Objective:

To determine the optimal scanning time point for

Ga-fibroblast activation protein inhibitor (FAPI)-04 positron emission tomography (PET)/computed tomography (CT) imaging and to evaluate the differences in the pharmacokinetics of

Ga-FAPI-04 between tumors and obstructive inflammation.

Methods:

A retrospective analysis of clinical data from patients who underwent

Ga-FAPI-04 PET/CT imaging due to abdominal tumors in The First Affiliated Hospital of Naval Medical University between January and November 2021 was conducted. The maximum standard uptake value (SUV

max

)

tumor-to-background ratio (TBR)

and signal-to-noise ratio (SNR) were compared across different time points using the Kruskal-Wallis H test

while the retention index (RI) for tumors and obstructive inflammation was analyzed using the Mann-Whitney

test.

Results:

A total of 31 patients were included in this study. The SUV max values for tumor lesions at 15 min

1 h

and 2 h were 8.52 (4.18–18.4)

8.59 (4.69–13.8)

and 7.64 (3.22–21.0)

respectively

with corresponding TBR values of 4.22 (1.87–17.76)

4.67 (2.20–29.05)

and 4.30 (2.48–35.20). Although the SUV

max

and TBR at 1 h were higher than those at other time points

the differences were not statistically significant (

＞0.05). The SNR values at 15 min

1 h

and 2 h were 6.41 (2.45–8.24)

5.0 (1.68–5.57)

and 3.02 (1.39–6.97)

showing significant differences (H value: 51.691

＜0.001)

with the highest SNR observed at 15 min. Furthermore

the RI for tumors at 15 min and 1 h was significantly higher than that for obstructive inflammation (-0.195–0.415

-0.422–0.115)

with a statistically significant difference (

=0.018).

Conclusion:

The image SNR is highest at 15 min after the inj

ection of

Ga-FAP1-04

making it a suitable time point for routine clinical scanning. Additionally

the RI at 15 min and 1 h is beneficial for distinguishing between tumors and obstructive inflammation.

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Comparison of image quality and clinical application value of 68 Ga-FAPI-04 PET/CT in multi-time point scanning of abdominal tumors

DOI：10.19732/j.cnki.2096-6210.2024.05.005

摘要

Abstract

关键词

Keywords

references

Comparison of image quality and clinical application value of ⁶⁸ Ga-FAPI-04 PET/CT in multi-time point scanning of abdominal tumors