Objective:

To explore the application value of contrast-enhanced ultrasound (CEUS)-computed tomography (CT)/ magnetic resonance imaging (MRI） fusion image virtual navigation in the biopsy of diffuse liver carcinoma.

Methods:

Patients with diffuse liver carcinoma detected by contrast-enhanced CT/MRI but not detected by conventional ultrasound in Nanjing Drum Tower Hospital were collected. The images of ultrasound and contrast-enhanced CT/MRI were fused b

y fusion imaging technology

and then CEUS was performed. The conventional ultrasound

CEUS

CT/MRI images and the visibility of the lesions were observed and analyzed. All patients underwent percutaneous liver biopsy under virtual navigation

and the success rate of puncture was summarized.

Results:

CEUS-CT/MRI fusion imaging was completed in all 21 cases

and the success rate of fusion was 100.0%. Under conventional ultrasound

none of the 21 cases could be displayed. In CEUS mode

66.7% (14/21) of the lesions were displayed in the arterial phase and 47.6% (10/21) in the delayed phase. Twenty-three percutaneous liver biopsies were performed under the guidance of virtual navigation. The positive rate of the first localization biopsy was 90.5% (19/21)

and 2 false negative cases obtained positive pathological results in the second biopsy.

Conclusion:

Fusion image-guided virtual navigation technology has a high value in the localization and qualitative diagnosis of diffuse liver carcinoma which is difficult to display by conventional ultrasound.