Site-specific development and preclinical evaluation of <sup>68</sup>Ga-THP-ACN376, a CLDN18.2-targeted nanobody probe

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Site-specific development and preclinical evaluation of ⁶⁸Ga-THP-ACN376, a CLDN18.2-targeted nanobody probe

更新时间：2025-12-15

- Site-specific development and preclinical evaluation of ⁶⁸Ga-THP-ACN376, a CLDN18.2-targeted nanobody probe
- “In the field of medical imaging, researchers have successfully constructed a PET probe 68Ga-THP-ACN376 targeting CLDN18.2, which has high labeling efficiency and stability, providing a new method for detecting CLDN18.2 protein expression.”
- Oncoradiology Vol. 34, Issue 5, Pages: 470-476(2025)
- 作者机构：
  
  1. 北京大学医学部医学技术研究院，北京 100191
  2. 北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科，消化系肿瘤整合防治全国重点实验室，国家药品监督管理局放射性药物研究与评价重点实验室，恶性肿瘤发病机制及转化研究教育部重点实验室，北京 100142
- 作者简介：
- 基金信息：
  
  Beijing Municipal Natural Science Foundation(Z250010);Youth Beijing Scholar 2024(113)
- DOI：10.19732/j.cnki.2096-6210.2025.05.005
  CLC：
- Received：24 September 2025，
  
  Published Online：06 November 2025，
  
  Published：28 October 2025
- 稿件说明：
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Chang LIU, Yuwen YANG, Zhi YANG, et al. Site-specific development and preclinical evaluation of ⁶⁸Ga-THP-ACN376, a CLDN18.2-targeted nanobody probe[J]. Oncoradiology, 2025, 34(5): 470-476.
DOI：

Chang LIU, Yuwen YANG, Zhi YANG, et al. Site-specific development and preclinical evaluation of ⁶⁸Ga-THP-ACN376, a CLDN18.2-targeted nanobody probe[J]. Oncoradiology, 2025, 34(5): 470-476. DOI： 10.19732/j.cnki.2096-6210.2025.05.005.

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