Comparison of correlations of reduced field-of-view and conventional apparent diffusion coefficients with Gleason score and percentage of tumor involvement in prostate core biopsy

LIU Xiaohang; ZHOU Liangping; PENG Weijun

doi:10.19732/j.cnki.2096-6212.2018.06.003

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Comparison of correlations of reduced field-of-view and conventional apparent diffusion coefficients with Gleason score and percentage of tumor involvement in prostate core biopsy

更新时间：2025-12-15

- Comparison of correlations of reduced field-of-view and conventional apparent diffusion coefficients with Gleason score and percentage of tumor involvement in prostate core biopsy
- Vol. 27, Issue 6, Pages: 442-447(2018)
- 作者机构：
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- DOI：10.19732/j.cnki.2096-6212.2018.06.003
  CLC：
- Published Online：16 January 2019，
  
  Published：16 January 2019
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刘晓航,周良平,彭卫军. 前列腺癌小视野、常规表观扩散系数与穿刺标本Gleason评分及肿瘤累及组织百分比的相关性比较[J]. 肿瘤影像学, 2018, 27(6): 442-447 https://doi.

org/10.19732/j.cnki.2096-6212.2018.06.003
刘晓航,周良平,彭卫军. 前列腺癌小视野、常规表观扩散系数与穿刺标本Gleason评分及肿瘤累及组织百分比的相关性比较[J]. 肿瘤影像学, 2018, 27(6): 442-447 https://doi. DOI： 10.19732/j.cnki.2096-6212.2018.06.003.

org/10.19732/j.cnki.2096-6212.2018.06.003 DOI：

摘要

目的：

比较前列腺癌小视野与常规表观扩散系数（apparent diffusion coefficient，ADC）值与穿刺标本Gleason评分、肿瘤累及组织百分比的相关性。

方法：

选取31例行小视野及常规扩散加权成像（diffusion weighted imaging，DWI）检查后经病理学检查证实的前列腺癌患者，以穿刺位置为单位，评价肿瘤可见性，测量所有前列腺癌的ADC值并进行比较，比较两种序列之间前列腺癌ADC值与Gleason评分和肿瘤累及组织百分比的相关关系，并单独评估不同肿瘤累及组织百分比（10%、11%~40%、41%~70%、71%~100%）组穿刺标本ADC值与Gleason评分的相关性。

结果：

共统计114处穿刺阳性位置的数据，小视野ADC图上肿瘤可见率（100/114）显著高于常规ADC图（86/114）（

0.05）。小视野与常规DWI上全部前列腺癌样本ADC值与Gleason评分呈负相关关系（

=-0.42和-0.41，

0.05），累及组织71%~100%组前列腺癌ADC值亦与Gleason评分呈负相关（

=-0.62和-0.56，

＜0.05），但其余各组无显著相关关系。前列腺癌ADC值与累及组织百分比亦呈负相关关系（

=-0.69和-0.63，

＜0.05），且相关系数高于ADC值与Gleason评分的相关性。

结论：

小视野前列腺ADC图可提高肿瘤的可见率，但ADC值受Gleason评分及肿瘤百分比的影响，对Gleason评分预测效果有限。

Abstract

Objective:

To compare the correlations of conventional and reduced field-of-view (FOV) apparent diffusion coefficient (ADC) with Gleason score and percentage of tumor involvement in prostate co

re biopsy.

Methods:

A total of 31 patients were confirmed prostate cancer by biopsy after conventional and reduced FOV diffusion weighted imaging (DWI). The cancer visibility on conventional and reduced FOV ADC maps was compared. The ADC value of cancer was measured by the two protocols

and the relationships between ADC value and Gleason score

percentage of tumor involvement were investigated. The relationship between ADC value and Gleason score was further assessed in biopsy samples with different percentages of tumor involvement (10%

11%-40%

41%-70%

71%-100%).

Results:

For 114 positive biopsy sites

cancer visibility on reduced FOV ADC map (100/114) was higher than that on conventional ADC map (86/114) (

0.05). Negative correlation between ADC value and Gleason score was observed for whole-sample (

=-0.42 and -0.41

0.05). There was a negative correlation between ADC value and Gleason score in the samples with 71%-100% of tumor involvement (

=-0.62 and -0.56

0.05). ADC value was also negatively correlated with percentage of tumor involvement (

=-0.69 and -0.63

0.05)

and the correlation coefficient was higher than that between ADCvalue and Gleason score.

Conclusion:

Reduced FOV ADC map could improve the visibility of prostate cancer

but ADC value is influenced by Gleason score and percentage of tumor involvement. So ADC value is limited in the prediction of Gleason score.

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