Comparative study of three dimensional pseudo-continuous arterial spin labeling and dynamic contrastenhanced MRI parameters in preoperative grading of gliomas
To comparatively study the difference between three dimensional pseudo-continuous arter
ial spin labeling (3D pCASL) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in the features of assessing the preoperative grading of gliomas.
Methods:
The data of 39 patients with proved gliomas (23 with high-grade gliomas and 16 with low-grade gliomas) from July 2014 to May 2016 were retrospectively analyzed. All patients were scanned on a 3.0T MRIsystem using conventional sequences
3D pCASL and DCE sequence. DCE-MRI parameters such as volume transfer constant (Ktrans)
extravascular extracellular space volume fraction (Ve)
fractional plasma volume (Vp)
tumor blood flow (TBF) and tumor blood volume (TBV) and 3D pCASL parameter cerebral blood flow (CBF) were measured and analyzed in different grades of gliomas
respectively using Omni-Kinetics Version 2.0 workstation and GE Advantage 4.5 workstation. Relative TBF (rTBF) and rCBF were obtained based on normalized mirror region and contralateral white matter. A correlation between rTBF on DCEMRI and rCBF on 3D pCASL was noted.
Results:
The differences in Ktrans
Ve
Vp
rTBF and rCBF values [(0.1620.026)/min
vs
. (0.0230.007)/min
0.8100.194
vs
. 0.4630.099
0.1180.026
vs
. 0.0550.017
2.8760.236
vs
. 1.6840.174
2.5740.160
vs
.1.1630.048
]
were statistically significant between high-grade glioma and low-grade glioma. There was certain correlation between rTBF on DCE-MRI and rCBF on 3D pCASL (
r
=0.62
P
0.05).
Conclusion
:
DCE-MRI parameters (Ktrans
Ve
Vp and rTBF) and ASL parameter (rCBF) might be useful in differentiating the preoperative grading of gliomas.