Value of combination of 18F-fluorodeoxyglucose PET/CT and serum carbohydrate antigen125 and human epididymis protein4 in diagnosis of recurrent or metastatic ovarian cancers
To analyze and discuss the value of combination of
18
F-fluorodeoxyglucose (
18
F-FDG) PET/CT and serum carbohydrate antigen 125 (CA125) or human epididymis protein 4 (HE4) in the diagnosis of recurrent or metastatic ovariancancer.
Methods:
The postoperative results of PET/CT
serum CA125 and HE4 of 63 cases of ovarian cancer w
ere analyzed retrospectively. The results were compared with surgical pathology or clinical follow-up data
so as to evaluate their values in the diagnosis of recurrent or metastatic ovarian cancer.
Results:
The overall sensitivity
specificity
accuracy
positive and negative predictive values of PET/CT were 94.00%
84.62%
92.06%
95.92% and 78.57%. The corresponding values of combination of PET/CT and serum HE4 were 98.00%
84.62%
95.24%
96.08% and 91.67%. CA125 level was positively correlated with maximum standardized uptake value (SUV
max
) of the recurrent or metastatic region.
Conclusion:
The diagnostic efficiency of
18
F-FDG PET/CT combined with HE4 is high in the diagnosis of recurrent or metastatic ovarian cancer.