血清糖类抗原125水平与<sup>18</sup>F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析

赵卫威; 李艳梅; 李鹏; 杨建伟; 韩慧杰

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血清糖类抗原125水平与¹⁸F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析

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- 血清糖类抗原125水平与¹⁸F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析
- Correlation analysis between serum carbohydrate antigen 125 level and ¹⁸F-fluorodeoxyglucose PET/CT in detecting recurrence and metastasis of ovarian cancer
- 肿瘤影像学 2016年25卷第1期页码：45-49
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- 网络出版：2016-05-04，
  
  纸质出版：2016-05-04
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赵卫威, 李艳梅, 李鹏, 等. 血清糖类抗原125水平与¹⁸F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析[J]. 肿瘤影像学, 2016,25(1):45-49.

赵卫威,李艳梅,李鹏,等. 血清糖类抗原125水平与¹⁸F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析[J]. 肿瘤影像学, 2016, 25(1): 45-49
赵卫威, 李艳梅, 李鹏, 等. 血清糖类抗原125水平与¹⁸F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析[J]. 肿瘤影像学, 2016,25(1):45-49. DOI：

赵卫威,李艳梅,李鹏,等. 血清糖类抗原125水平与¹⁸F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析[J]. 肿瘤影像学, 2016, 25(1): 45-49 DOI：

摘要

目的：

针对临床怀疑卵巢癌术后复发和转移的患者，比较糖类抗原125(carbohydrate antigen 125，CA125)及

F-脱氧葡萄糖(18F-fluorodeoxyglucose，

F-FDG)PET/CT探测卵巢癌复发及转移的效能，探讨两者关系，以发现最优化的检测手段。

方法：

157例卵巢癌术后临床怀疑复发或转移的患者均进行CA125及PET/CT检查，两者时间间隔少于7 d。

结果：

PET/CT显像阳性97例，阴性60例，两组的CA125值分别为(188.61202.70)U/mL、(32.4967.61)U/mL，差异有统计学意义(

＜0.001)。根据国际妇产科联盟(International Federation of Gynecology and Obstetrics，FIGO)卵巢癌分期，Ⅱ期患者16例、Ⅲ期33例、Ⅳ期48例，CA125分别为(155.73174.23)U/mL、(181.01211.70)U/mL、(204.80207.48)U/mL，最大标准摄取值(maximum standardized uptake value，SUV

max

)分别为8.454.18、8.793.55、9.324.33，3组之间CA125和SUV

max

差异无统计学意义。CA125与SUV

max

之间存在低度相关(

=0.203，

=0.046)。CA125预测PET/CT显像阳性的受试者工作特征（receiver operating characteristic，ROC）曲线的最佳切点值为19.07 U/mL，最大曲线下面积为0.871(0.810~0.931)，灵敏度为89.7%，特异度为81.7%，阳性预测值为86.1%，阴性预测值为85.7%。

结论：

血清CA125与PET/CT显像检测卵巢癌复发和转移有较好的一致性，特别是对CA12519.07 U/mL的卵巢癌术后患者，PET/CT尤为适用。

Abstract

Objective:

For the clinical suspicion of recurrence and metastasis of ovarian cance

the diagnostic efficacies of serum carbohydrate antigen 125 (CA125) and

F-fluorodeoxyglucose (

F-FDG) PET/CT were compared and their relationship was analyzed.

Methods:

18F-FDG PET/CT and serum CA125 assay were performed in 157 postoperative patient with ovarian cancer

and the time interval was less than 7 d.

Results:

PET/CT imaging detected 97 positive and 60 negative. The levels of CA125 were (188.61202.70) U/mL and (32.4967.61) U/mL in the positive group and negative group

respectively. There was significant difference (

0.001). According to International Federation of Gynecology and Obstetrics (FIGO) staging of ovarian cancer

16 werestage Ⅱ

33 stage Ⅲ and 48 stage Ⅳ. The levels of CA125 were (155.73174.23) U/mL

(181.01211.70) U/mL and (204.80207.48) U/mL

respectively. The corresponding SUV

max

values were 8.454.18

8.793.55 and 9.324.33. There was no significant difference in CA125 level and SUVmax value among three groups. There was a weak correlation between CA125 level and SUVmax value (

=0.203

=0.046). The receiver operating characteristic (ROC) curve analysis revealed that the optimal cut-off of CA125 level to predict positive

F-FDG PET/CT result was 19.07 U/mL

the area under curve (AUC) was 0.871 (0.810-0.931)

the sensitivity was 89.7%

the specificity was 81.7%

the positive predictive value was 86.1%

and the negative predictive value was 85.7%.

Conclusion:

Serum CA125 and PET/CT imaging in detecting the recurrence and metastasis of ovarian cancer have better consistency. Especially in the ovarian cancer patients with CA12519.07 U/mL

PET/CT is particularly applicable.

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血清糖类抗原125水平与18F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析

Correlation analysis between serum carbohydrate antigen 125 level and 18F-fluorodeoxyglucose PET/CT in detecting recurrence and metastasis of ovarian cancer

DOI：

摘要

Abstract

关键词

Keywords

references

血清糖类抗原125水平与¹⁸F-脱氧葡萄糖PET/CT诊断卵巢癌复发和转移效能的相关性分析

Correlation analysis between serum carbohydrate antigen 125 level and ¹⁸F-fluorodeoxyglucose PET/CT in detecting recurrence and metastasis of ovarian cancer