Objective:

To observe the inhibitory effects of paclitaxel (PTX)-loaded nanoparticle (NP) gel system combined with ultrasonic irradiation on the growth of C6 glioma cells.

Methods:

Five groups were set up: Control

BLANK-NP-GEL

PTX

PTX-NP-GEL and PTX-NP-GEL-US. They were administered to C6 glioma cells respectively. The relative growth rate (RGR) of cells was detected by methyl thiazolyl tetrazolium (MTT) method

and the inhibitory effects on the growth of C6 glioma cells were observed.

Results:

The nano m

aterials had no obvious inhibitory effects on cell proliferation. Paclitaxel could obviously inhibit cell proliferation compared to control group

(P

0.05). There were significant differences in RGR among PTX

PTX-NP-GEL and PTXNP- GEL-US groups (

P

0.05).

Conclusion:

The selected nanoparticle gel system materials have fine biocompatibility. Paclitaxel can inhibit the growth of C6 glioma cells. The paclitaxel-loaded nanoparticle gel system has sustained release effect

and ultrasonic irradiation can promote drug release.