<sup>18</sup>F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究

周维燕; 文剑波; 华逢春; 孔艳艳; 张政伟; 陆秀宏; 管一晖

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¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究

专题论著 | 更新时间：2025-12-15

- ¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究
- Relationship between ¹⁸F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma
- 肿瘤影像学 2016年25卷第3期页码：257-262
- 作者机构：
  
  1. 复旦大学附属华山医院PET中心,上海,200235
  2. 复旦大学附属华山医院放射科,上海,200040
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 网络出版：2016-11-02，
  
  纸质出版：2016-11-02
- 稿件说明：
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周维燕, 文剑波, 华逢春, 等. ¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究[J]. 肿瘤影像学, 2016,25(3):257-262.

周维燕,文剑波,华逢春,等. ¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究[J]. 肿瘤影像学, 2016, 25(3): 257-262
周维燕, 文剑波, 华逢春, 等. ¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究[J]. 肿瘤影像学, 2016,25(3):257-262. DOI：

周维燕,文剑波,华逢春,等. ¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究[J]. 肿瘤影像学, 2016, 25(3): 257-262 DOI：

摘要

目的：

本研究回顾性分析原发性中枢系统淋巴瘤(primary central nervous system lymphoma，PCNSL)病灶

F-脱氧葡萄糖(

F-fluorodeoxyglucose，

F-FDG)半定量摄取与表观扩散系数(apparent diffusion coefficient，ADC)之间的关系。

方法：

纳入14例在复旦大学附属华山医院同时行FDG PET/CT及弥散加权成像(diffusion weighted imaging，DWI)检查的初诊PCNSL患者。手动在经滤波反投影(filtered back projection，FBP)重建后的脑PET图勾画PCNSL病灶感兴趣区(region of interest，ROI)，测算肿瘤FDG摄取半定量参数平均标准摄取值(mean standardized uptake value，SUVmean)及最大标准摄取值(maximum standardzed uptake value，SUVmax)。在ADC图上肿瘤实质、对侧相应正常脑白质区各自勾画ROI并分别测定ADC值，病灶ADC值取最小值(ADCmin)，对侧正常脑白质ADC值取平均值(ADCmean)，rADC为病灶ADCmin与对侧正常脑白质ADCmean的比值。采用Pearson分析对SUV与ADC半定量参数之间的相关性进行分析。

结果：

14例PCNSL患者共计纳入18个病灶，SUVmax与rADC(

=-0.584，

=0.011)、SUVmean与rADC(

=-0.559，

=0.016)均呈负相关。

结论：

基于病灶分析的治疗前SUV与ADC值存在负相关，PCNSL肿瘤细胞的代谢信息与其致密程度存在相关性，为DWI作为FDGPET诊断PCNSL和进行疗效监测的替代技术提供了一定的理论依据。

Abstract

Objective:

To retrospectively evaluate the relationship between

F-fluorodeoxyglucose (

F-FDG) uptake using PET/CT and apparent diffusion coefficient

(ADC) in patients with primary central nervous system lymphoma (PCNSL).

Methods:

A total of 14 PCNSL cases with 18 lesions underwent both FDG PET/CT scan and diffusion weighted imaging at onset. The meanstandardized uptake value (SUVmean) and maximum standardized uptake value (SUVmax) were calculated to assess the tumor FDG uptake on brain PET/CT images with filtered back projection (FBP) reconstruction. On ADC map

ADCmin of the lesions and ADCmean of the contralateral normal white matters were calculated. The relative ADC (rADC) was obtained by the ratio of ADCmin of the tumor to ADCmean of the contralateral normal white matter. Pearsons correlation analysis was used to assess the relationship between FDG uptake and ADC-derived parameters.

Results:

Negative correlations between SUVmax and rADC

between SUVmean and rADC were found for PCNSL cases (

=-0.584

=0.011;

=-0.559

=0.016

respectively).

Conclusion:

There is negative correlation between SUV and rADC before treatment. Both FDG PET/CT and DWI are useful methods in diagnosing PCNSL by evaluating tumor metabolic activity and cellular density. They are closely correlated. DWI could be an alternative imaging technique for FDG PET/CT in the diagnosis and therapy monitoring of PCNSL.

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18F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究

Relationship between 18F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma

DOI：

摘要

Abstract

关键词

Keywords

references

¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究

Relationship between ¹⁸F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma