The liver is the largest gland in the body. Focal liver lesions are the clinical common liver diseases with complex pathological types. Their treatment and prognosis are significantly different. So the differential diagnosis of focal liver lesions becomes urgent in clinic. In recent years

the second generation contrast agents and the low mechanical index realtime scanning technology have developed rapidly. As a noninvasive technique

contrast-enhanced ultrasound can clearly display the intrahepatic vessels

intrahepatic tissues and intrahepatic lesions

then evaluate the period of vascular perfusion in the liver to improve the diagnostic accuracy. The contrast-enhanced ultrasonographic features of different focal liver lesions are reviewed in the present paper.