Objective:

To investigate the diagnostic value of contrast-enhanced ultrasound (CEUS) in gestational trophoblastic neoplasia (GTN).

Methods:

Thirty-seven cases with 41 suspicious GTNs were reviewed

which were examined by conventional ultrasound and CEUS from August 2015 to July 2016 in West China Second University Hospital

Sichuan University. Malignant masses were enrolled in GTN group including 30 cases with 34 masses and benign masses were enrolled in non-GTN group including 7 cases with 7 masses. All the masses were confirmed by gold standard (pathological results and cl

inical cure).

Results:

The enhancement patterns of GTNs: 44.12% (15/34) showed regional enhancement

29.41% (10/34) showed diffuse enhancement. The enhancement patterns of non-GTNs: 5 cases with pregnancy residues showed regional enhancement

2 cases withmass-type uterine ectopic pregnancy showed ring-like enhancement. There were significant differences in the parameters of timeintensity curve between GTNs or non-GTNs and normal muscle layer (

P

0.05). All lesions showed earlier initial time and peak time

greater enhancement rate and higher peak intensity than the normal muscle layer. Compared with the gold standard

the coincidence rates of ultrasound and CEUS in the diagnosis of benign or malignant pregnancy-associated uterine diseases were 82.93% (34/41) and 92.68% (38/41)

respectively.

Conclusion:

The CEUS features of benign and malignant pregnancy-associated uterine diseases were different

which are helpful in the differential diagnosis. In addition

CEUS provides more accurate information and application value.