Objective:

To investigate the clinical features and sonographic characteristics of intermediate trophoblastic tumor (ITT).

Methods:

Eleven cases of ITT were identified at The First Affiliated Hospital of Sun Yet-sen University between January 2003 and December 2016

and the clinical features and findings on ultrasound were investigated.

Results:

The most frequent symptoms associated with ITT were abnormal vaginal bleeding

which was present in 10 cases

and amenorrhea

which was present in 7 cases. The interval from anteced

ent pregnancy to diagnosis was 234 months (median

16.3 months). The serum level of -human chorionic gonadotropin (-HCG) was generally low

with a median of 277 IU/L (range

2.929 608 IU/L). The findings on ultrasound were classified according to the location of the lesions. Type I

lesions located in the uterine cavity (1 case with solid mass

1 case with alveolate mass); Type Ⅱ

lesions located both within the uterine cavity and myometrium (3 cases with solid masses

1 case with alveolate mass); Type III

lesions located in the myometrium (2 cases with solid masses

1 case with alveolate mass

2 cases with cystic lesions). The solid masses presented with minimal to a high degree of vascularization. Both the alveolate and cystic lesions were highly vascularized.

Conclusion:

Combined with clinical features

the findings on ultrasound could lead to the suspicion of ITT and contribute to clinical diagnosis.