Objective:

To evaluate the roles of compression elastography and serum monocyte chemoattractant protein 1 (MCP-1) level in the differential diagnosis of begin and malignant breast tumors.

Methods:

A total of 60 patients with liver lesions were selected from International Peace Maternity Child Health Hospital

Shanghai Jiao Tong University School of Medicine from January to June 2o16. They underwent the conventional ultrasound and compression elastography examinations and strain ratio (SR) was ob

tained. Luminex liquid chip technology was used to analyze the level of MCP-1 in serum. The two methods alone and in combination were applied in this study. The pathological results were set as the gold standard and used to evaluate the diagnosis efficiency in differential diagnosing benign and malignant breast tumors.

Results:

With the cutoff value of SR at 4.87

the sensitivity and specificity of compression elastography in the diagnosis of malignant breast tumor were 83.33% and 70.81%. With the cutoff value of serum MCP-1 level at 45.6 pg/mL

the sensitivity and specificity of compression elastography in the diagnosis of malignant breast tumor were 100.0% and 91.7%. When the two methods were combined

the area under receiver operating characteristic (ROC) curve was 0.99

with statistical difference in comparison with compression elastography alone (

P

=0.002 5). Further correlation analysis showed that there was apositively correlation between SR value and MCP-1 level in serum (

r

=0.732

P

0.000).

Conclusion:

The combination of compression elastography and serum MCP-1 level is useful for the differential diagnosis of benign and malignant breast tumors.