Objective:

To explore the value of contrast-enhanced ultrasound (CEUS) in the diagnosis of breast cancer with neoadjuvant chemotherapy.

Methods:

A nude mouse model of human breast cancer was established

and the clinical drug administration program was simulated. After chemotherapy

the data of tumor biology

ultrasound imaging and blood vessel microcirculation index were measured.

Results:

Tumor vascular endothelial growth factor receptor 1 (VEGFR-1) showed a significant decrease after the early stage of chemotherapy

and the microvascular density (MVD) decreased significantly after the second chemotherapy. The peak intensity (IMAX) of tumor perfusion significantly decreased after the early stage of chemotherapy

and the time to peak (TTP) significantly increased after the second chemotherapy.

Conclusion:

The changes in some indexes of CEUS are c

onsistent with the changes in some tumor microcirculation indexes

although the correlation between them has not been confirmed and needs further research.