<sup>99m</sup>Tc-HYNIC-TOC SPECT/CT显像中胰头高摄取的判读：生理性摄取或胰腺神经内分泌瘤？

徐俊彦; 李毅; 许晓平; 李蓓; 章英剑

doi:10.19401/j.cnki.1007-3639.2018.03.003

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^99mTc-HYNIC-TOC SPECT/CT显像中胰头高摄取的判读：生理性摄取或胰腺神经内分泌瘤？

专题论著 | 更新时间：2025-12-15

- ^99mTc-HYNIC-TOC SPECT/CT显像中胰头高摄取的判读：生理性摄取或胰腺神经内分泌瘤？
- Interpretation of high uptake of pancreatic head identified by ^99mTc-HYNIC-TOC SPECT/CT: physiological uptake or neuroendocrine tumor?
- 肿瘤影像学 2018年27卷第3期页码：140-144
- 作者机构：
  
  1. 上海分子影像探针工程技术研究中心,上海,200032
  2. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  3. 复旦大学生物医学影像研究中心,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2018.03.003
  中图分类号：
- 网络出版：2018-07-26，
  
  纸质出版：2018-07-26
- 稿件说明：
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徐俊彦,李毅,许晓平,等. ^99mTc-HYNIC-TOC SPECT/CT显像中胰头高摄取的判读：生理性摄取或胰腺神经内分泌瘤？[J]. 肿瘤影像学, 2018, 27(3): 140-144 https://doi.

org/10.19401/j.cnki.1007-3639.2018.03.003
徐俊彦,李毅,许晓平,等. ^99mTc-HYNIC-TOC SPECT/CT显像中胰头高摄取的判读：生理性摄取或胰腺神经内分泌瘤？[J]. 肿瘤影像学, 2018, 27(3): 140-144 https://doi. DOI： 10.19401/j.cnki.1007-3639.2018.03.003.

org/10.19401/j.cnki.1007-3639.2018.03.003 DOI：

摘要

目的：

本研究旨在探讨如何准确判断

99m

Tc-HYNIC-TOC SPECT/CT显像中胰头高摄取灶的性质。

方法：

回顾性分析125例

99m

Tc-HYNIC-TOC SPECT/CT检查患者，包括可疑胰腺神经内分泌瘤（pancreatic neuroendocrine tumor，pNET）或远处转移性NET寻找原发灶或明确NET行临床分期或随访者。根据视觉判断评价SPECT/CT图像上是否存在胰头高摄取，若存在高摄取，测量病灶部位、胰腺本底、肝脏本底及同层面竖脊肌本底的放射性计数，并计算得到病灶/胰腺本底比（L/P）、病灶/肝脏本底比（L/H）和病灶/肌肉本底比（L/M）。通过影像学随访或病理证实获取最终诊断结果。

结果：

125例患者中，20例（16.0%）手术或穿刺病理证实为pNET，22例（17.6%）长期随访局部未见病灶，考虑为生理性摄取。pNET与胰头生理性摄取的L/P差异无统计学意义（

=0.118），前者的L/H和L/M明显高于后者（

=0.001和0.013）。受试者工作特征（receiver operating characteristic，ROC）曲线分析显示，L/H和L/M判别pNET还是胰头生理性摄取的曲线下面积（area under curve，AUC）为0.789和0.725，此时L/H阈值为1.4。

结论：

通过L/H测定，有助于判断

99m

Tc-HYNIC-TOC SPECT/CT显像中胰头高摄取灶为胰腺生理性摄取还是pNET。

Abstract

Objective:

To discuss how to determine the property of high uptake of pancreatic head identified by

99m

Tc-HYNIC-TOC SPECT/CT.

Methods:

We retrospectively analyzed 125 patients who underwent

99m

Tc-HYNIC-TOC SPECT/CT for suspecious pancreatic neuroendocrine tumor (pNET) or staging and restaging of NET or detecting primary tumor for metastatic NET. High uptake of pancreatic head in the image of SPECT/ CT was defined by visual assessment. If it existed

the radioactive counts of high-uptake lesion

normal pancreas

normal hepatic tissue and normal muscle were measured and the ratios of lesion-to-pancreas (L/P)

lesion-to-hepatic tissue (L/H) and lesion-to-muscle (L/M) were calculated. The final results were achieved by imaging follow-up or pathological confirmation.

Results:

Twenty (16.0%) patients were confirmed as pNET by surgery or biopsy. Twenty-two (17.6%) patients were considered as physiological uptake because of lack of abnormal masses located in the pancreatic head. There was no significant difference in L/P between pNET and physiological uptake (

=0.118). However

L/H and L/M of pNET were significantly higher than those of physiological uptake (

=0.001 and 0.013). The areas under curve by receiver operating characteristic (ROC) curve analysis of L/H and L/M for distinguishing pNET from physiological uptake were 0.789 and 0.725

respectively.

Conclusion:

It is a useful way to differentiate pNET from physiological uptake in

99m

Tc-HYNIC-TOC SPECT/CT by measuring the ratio of L/H.

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99mTc-HYNIC-TOC SPECT/CT显像中胰头高摄取的判读：生理性摄取或胰腺神经内分泌瘤？

Interpretation of high uptake of pancreatic head identified by 99mTc-HYNIC-TOC SPECT/CT: physiological uptake or neuroendocrine tumor?

DOI：10.19401/j.cnki.1007-3639.2018.03.003

摘要

Abstract

关键词

Keywords

references

^99mTc-HYNIC-TOC SPECT/CT显像中胰头高摄取的判读：生理性摄取或胰腺神经内分泌瘤？

Interpretation of high uptake of pancreatic head identified by ^99mTc-HYNIC-TOC SPECT/CT: physiological uptake or neuroendocrine tumor?