Objective:

To systematically review the diagnostic value of diffusion kurtosis imaging (DKI) in prostate cancer by meta-analysis

and to quantitatively analyze the kurtosis coefficient (Kapp) of prostate cancer tissue and non-cancerous tissue

so as to provide evidence-based basis for clinical decision-making.

Methods:

The database i

ncluding PubMed

EMBASE

EBSCO

Cochrane Library

CNKI

CBM

and VIP were electronically searched from inception to July 31

2017

to collect diagnostic articles about DKI in prostate cancer. Two reviewers independently screened the literatures

extracted data and assessed the methodological quality of included articles by QUADAS tool. Then

the relevant parameters were extracted by applying meta-Disc 1.4 and Stata 12.0 softwares.

Results:

A total of 7 articles met the inclusion criteria

409 patients were included

and the number of regions of interest was 804. The fixed effect model was used due to no heterogeneity. The results of Meta-analysis showed that Kapp value in prostate cancer tissue was significantly higher than that in non-cancerous tissue and the pooled sensitivity

specificity

positive likelihood ratio

negative likelihood ratio

and diagnostic odds ratio (DOR) were 0.943 [95%CI: 0.915-0.962

]

0.917 [95%CI: 0.829-0.962

]

11.365 [95%CI: 5.287-24.427

]

0.063 [95%CI: 0.041-0.096

]

181.803 [95%CI: 65.267-506.419

]

respectively

the area under the receiver operating characteristic curve was 0.96.

Conclusion:

DKI has a high value and good sensitivity and specificity in diagnosis of prostate cancer.