肺内直径&le;10 mm纯磨玻璃密度结节进展的危险因素分析

阎守芳; 高慧; 邹立秋; 张凯; 褚千琨

doi:10.19732/j.cnki.1008-617X.2018.05.015

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肺内直径≤10 mm纯磨玻璃密度结节进展的危险因素分析

论著 | 更新时间：2025-12-15

- 肺内直径≤10 mm纯磨玻璃密度结节进展的危险因素分析
- Risk factors of progression of pulmonary pure ground glass nodules less than or equal to 10 mm
- 肿瘤影像学 2018年27卷第5期页码：412-415
- 作者机构：
- 作者简介：
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- DOI：10.19732/j.cnki.1008-617X.2018.05.015
  中图分类号：
- 网络出版：2018-11-14，
  
  纸质出版：2018-11-14
- 稿件说明：
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阎守芳,高慧,邹立秋,等. 肺内直径10 mm纯磨玻璃密度结节进展的危险因素分析[J]. 肿瘤影像学, 2018, 27(5): 412-415 https://doi.

org/10.19732/j.cnki.1008-617X.2018.05.015
阎守芳,高慧,邹立秋,等. 肺内直径10 mm纯磨玻璃密度结节进展的危险因素分析[J]. 肿瘤影像学, 2018, 27(5): 412-415 https://doi. DOI： 10.19732/j.cnki.1008-617X.2018.05.015.

org/10.19732/j.cnki.1008-617X.2018.05.015 DOI：

摘要

目的：

探讨肺内直径10 mm纯磨玻璃密度结节（pure ground glass nodule，pGGN）进展的危险因素。

方法：

将2010年3月2016年3月广东省深圳市南山人民医院收治的67例经CT检查确诊为肺部pGGN的患者作为研究对象，均为单一病灶，结节最大径10 mm，确诊后接受12个月的随访。根据随访期内病灶是否增大和（或）出现实性成分，分为观察组11例和对照组56例，前者病灶增大和（或）出现实性成分，后者病灶大小无变化且始终未出现实性成分。对比分析两组患者的临床资料，并对有统计意义的项目进一步行非条件Logistic回归分析。

结果：

两组患者性别（

=0.048 7，

=0.846 3）、年龄（

=0.179 3，

=0.858 3）、结节直径（

=0.491 9，

=0.624 5）、结节形状（

=0.036 0，

=0.870 0）、病灶边缘特征（

=2.455 0，

=0.307 1）、瘤肺界面清楚情况（

=0.288 7，

=0.615 2）相比差异无统计学意义；观察组结节密度（

=2.229 6，

=0.029 2）、空气支气管征阳性率（

=6.424 0，

=0.011 9）、血管改变阳性率（

=5.815 9，

=0.017 6）显著高于对照组，差异有统计学意义。多因素非条件Logistic回归分析显示，结节密度（

=5.030 6，

=0.024 9）、空气支气管征（

=5.229 5，

=0.022 2）是肺部10 mm的pGGN进展的独立危险因素，血管改变是其非独立相关因素（

=1.971 1，

=0.160 3）。

结论：

对于肺部10 mm的pGGN患者，结节密度-500 HU或空气支气管征呈阳性时应加强监测，以早期发现进展并及时给予治疗。

Abstract

Objective:

To analyze the risk factors of progression in of pulmonary pure ground glass nodules (pGGNs) less than or equal to 10 mm.

Methods:

A total of 67 cases with pulmonary pGGN diagnosed by CT examination were selected. All patiets had single lesions less than or equal to 10 mm

and received 12-month follow-up after diagnosis. They were divided into the observation group (11 cases) and the control group (56 cases) according to lesion enlargement and (or) appearance of solid components during the follow-up period. The observation group had enlarged lesions and (or) appearance of solid components. The control group had no changes in the size of lesions and no appearance of solid components. The clinical data of the two groups were compared and analyzed

and the items with statistical significance were analyzed by Logistic regression analysis.

Results:

There was no significant difference in gender (

=0.048 7

=0.846 3)

age (

=0.179 3

=0.858 3)

nodule diameter (

=0.491 9

=0.624 5)

nodule shape (

=0.036 0

=0.870 0)

lesion edge (

=2.455 0

=0.307 1)

lung tumor interface (

=0.288 7

=0.615 2) between the two groups. The positive rates of nodule density (

=2.229 6

=0.029 2)

air bronchogram sign (

=6.424 0

=0.011 9) and vascular changes (

=5.815 9

=0.017 6) in the observation group were significantly higher than those in the control group. The multivariate nonconditional Logistic regression analysis showed that nodule density (

=5.030 6

=0.024 9) and air bronchogram sign (

=5.229 5

=0.022 2) were independent risk factors of progression of pulmonary pGGNs less than or equal to 10 mm

and the vascular changes were indepen

dently related factors (

=1.971 1

=0.160 3).

Conclusion:

The patients with pulmonary pGGNs less than or equal to 10 mm should be strengthened monitoring

when the nodule density is higher than －500 HU or air bronchogram signs appear

in order to find out the progression and administer timely treatment in early stage.

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肺内直径≤10 mm纯磨玻璃密度结节进展的危险因素分析

Risk factors of progression of pulmonary pure ground glass nodules less than or equal to 10 mm

DOI：10.19732/j.cnki.1008-617X.2018.05.015

摘要

Abstract

关键词

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