Objective:

To investigate the correlation between ultrasonographic features and the positive rates of estrogen receptor (ER)

progesterone receptor (PR) and Ki-67 in breast invasive ductal carcinoma (IDC).

Methods:

The ultrasonographic features of 79 cases with breast IDC confirmed by patholog

y were analyzed retrospectively

including tumor size

edge

shape

calcification

blood flow signal

lymph node metastasis

etc. Immunohistochemical method was used to detect the positive rates of ER

PR and Ki-67. The correlations between ultrasonographic features and ER

PR and Ki-67 positive rates were analyzed.

Results:

The positive rates of ER

PR and Ki-67 in breast IDC were 59.5%

58.2%

69.6%

respectively. Spicular sign on ultrasonographic images and negative axillary lymph node metastasis were correlated with high positive rates of ER and PR (

P

＜0.05). The microcalcifications

blood flow grade 2-3 and positive axillary lymph node metastasis were correlated with high Ki-67 proliferative index (

P

＜0.05). Tumor size and shape were not correlated with the expressions of ER

PR and Ki-67.

Conclusion:

There are certain correlations between ultrasonographic features and the positive rates of ER

PR and Ki-67. Sonographic findings could indicate biological behaviors of IDC in some ways

and provide more evidence for the degree of malignancy and prognosis of IDC.