Objective：

To investigate the feasibility of differentiating

c-kit

/platelet-derived growth factor receptor alpha (

PDGFRA

) gene mutations in gastrointestinal stromal tumors (GI

STs) based on CT texture analysis.

Methods:

The contrast-enhanced CT features of 140 GIST patients confirmed by molecular pathology were retrospectively analyzed (126 with

c-kit

mutation

14 with

PDGFRA

mutation). Texture features were extracted using LIFEx package. Mann-Whitney

U

test was used to compare the difference in the parameters between the patients with

c-kit

and

PDGFRA

mutations. The differentiation performance was evaluated by the area under curve (AUC) of receiver operating characteristic (ROC) curve.

Results:

GIST patients with

c-kit

mutation exhibited higher short-zone emphasis (SZE)

higher short-zone high gray-level emphasis (SZHGE) and higher zone percentage (ZP) than those with

PDGFRA

mutation (

P

＜0.05). There was no statistically significant difference in other texture parameters between the two groups (

P

＞0.05). The SZE

SZHGE and ZP successfully showed the differentiation performance between GIST patients with

c-kit

and

PDGFRA

mutations with AUCs of 0.69

0.70 and 0.71 (

P

＜0.05)

sensitivities of 46.03%

47.62% and 78.57%

specificities of 92.86%

92.86% and 64.29%

accuracies of 83.57%

83.57% and 90.00%

respectively.

Conclusion:

CT texture analysis has certain values in differentiating

c-kit

mutation from

PDGFRA

mutation in GIST patients.