Objective:

To investigate the clinical eff icacy of microwave inactivation combined with

125

I seeds brachytherapy in osteosarcoma in children following effective neoadjuvant intra-arterial chemotherapy.

Methods:

From Mar. 2011 to Sep. 2016

19 children who were suffering from limb osteosarcoma

they were eleven male and eight female patients

average 8 years old

ⅠB for 3 cases

ⅡA for 2 cases

ⅡB for 14 cases according to Ennekings surgical staging system. All patient

s received neoadjuvant intraarterial chemotherapy before surgery

and received microwave inactivation in situ combined with 125I seeds brachytherapy. Allograft bone or bone cement f illing was adopted for repairing the bone defect

and the bone affected was f ixed by using internal f ixation. The mean follow-up was 47 months.

Results:

One patient died of lung metastasis. There was no local infection

recurrences

fracture

looseness or rupture of internal fixation

and no radiation injury of blood vessels or nerves. According to evaluation criteria for postoperative function of skeletal muscle tumors in Enneking

the average functional score was 86.7% (26/30) and the excellent and good rate was 89.5%.

Conclusion:

On the premise of effective neoadjuvant chemotherapy

the microwave inactivation combined in situ with

125

I seeds brachytherapy can result in satisfactory limb length and joint function for children with osteosarcomar. Meanwhile

as a type of brachytherapy

125

I seeds implantation could effectively prevent local recurrence after surgery.