Objective:

To investigate the correlation between dynamic contrast-enhanced magnetic resonance

imaging (DCE-MRI) features and molecular prognostic markers in breast cancer.

Methods:

The preoperative DCE-MRI image features of 68 patients with breast cancer were analyzed retrospectively

and the difference in DCE-MRI image features among different molecular prognostic markers were compared.

Results:

Compared with estrogen receptor (ER) positive

the proportion of large lesions (2 cm) and smooth edge of lesions were significantly increased in negative ER (

2

=4.55

8.27;

P

＜0.05). Compared with progesterone receptor (PR) positive

the proportion of smooth edge of lesions in PR negative patients was significantly increased (

2

=7.23;

P

＜0.05). Compared with human epidermal growth factor receptor-2 (HER2) positive

the proportion of large lesions in those with negative HER2 was significantly reduced (

2

=4.57;

P

＜0.05). Compared with Ki-67 positive

negative Ki-67 patients had significantly lower proportion of large lesion and smooth edge of lesions (

2

=4.72

7.88;

P

＜0.05). The peak time of MRI in breast cancer patients was (203.1515.46) s

and the rate of early enhancement was (125.1718.24) %. The peaking time was positively correlated with the positive expression of ER and PR (

r

=0.388

0.359;

P

＜0.05)

but was not significantly correlated with HER2 expression and Ki-67 labeling index (

r

=-0.281

-0.310;

P

＞0.05).

Conclusion:

DCE-MRI image features of breast cancer

especially tumor size

marginal state and rate of early enhancement

are well correlated with the expressions of PR

ER

HER2 and Ki-67 labelingindex

which can provide reference for preoperative prediction

treatment plan formulation and prognosis evaluation of breast cancer.