Objective:

To investigate the relationship between the change of microcalcification and tumor pathological response after neoadjuvant chemotherapy in breast cancer.

Methods:

The changes of calcification amount and its relationship with calcification morphology before and after neoadjuvant chemotherapy in 88 breast cancer patients were analyzed retrospectively.

Results:

88 cases of breast cancer meet the standard

and after neoadjuvant chemotherapy

23 cases of patients whose number of calcification werereduced; 55 patients remained stable

10 cases increased. Patients whose n

umber of calcification were reduced after neoadjuvant chemotherapy had higher rates of pathological complete remission than patients with stable calcification. Patients whose Miller Payen (MP) classification were Ⅳ and Ⅴ were 87.0% in patients with reduced number of calcification. Patients whose MP classification were Ⅰ and Ⅱ were 80.0% in patients with increased number of calcification. In cases of whose calcification number were reduced

there were 69.6% patients whose calcification was only distributed in the mass

and cases of whose calcification number were increased had no type like this (the number of calcified lesions was not distributed in the mass). The proportion of small pleomorphic and thin or thin branched calcification in patients whose number of calcification were decreased after neoadjuvant chemotherapy was 78.3%.

Conclusion:

The changes of the number of calcifications after neoadjuvant chemotherapy had relationship with MP classification

the distribution of calcification and the morphology of calcification. But calcification remained stable in most breast cancer patients after neoadjuvant chemotherapy.