Objective:

To discuss the mammographic density (MD) assessment by Quantra software as compared to Breast Imaging Reporting and Data Systems (BI-RADS).

Methods:

Retrospective analysis of 4 028 cases of female patients with mammography at Tianjin Medical Un

iversity Cancer Institute and Hospital was performed. Images of mammography were analyzed with Quantra software

the computer automatically calculated the MD

q_abd value and Q_abd value. Two experienced radiologists read the mammograms and assessed the MD with BI-RADS classification. Statistical analysis was carried out with SPSS 19.0 soffware by using Kappa test for analyzing the consistency between Q_abd value and BI-RADS. To calculate the consistency analysis between the MD measured by Quantra software and BI-RADS. Receiver operating characteristic (ROC) curve was used to analyze between Q_abd value and BI-RADS (two-grade scale) with the area under curve (AUC)

95% CI

sensitivity

specificity and limit value.

Results:

Agreement (weighted Kappa) between BI-RADS and Quantra was 0.665 and 0.760 on four- and two-grade scales

respectively. The AUC

95% CI

sensitivity

specificity and cut-off value was 0.957

0.951-0.964

86.0%

99.2% and 13%

respectively.

Conclusion:

Quantra software is a relatively simple

objective and accurate method to evaluate MD

and can effectively avoid more dependent on subjective judgment of the radiologist.