Objective:

To analyze the value of ultrasound-guided fine-needle aspiration biopsy (US-FNAB) combined with washout fluid thyroglobulin in fine-needle aspiration (FNA-Tg)

and pathological tissue CD57 in diagnosis of papillary thyroid carcinoma (PTC).

Methods:

From Dec. 2016 to Jun. 2018 in Second Hospital of Hebei Medical University

220 patients were selected

and 120 cases were of PTC

and 100 cases were of benign thyroid lesions (BTL). Immunohistochemistry was used to detect the expression of CD57 in pathological tissues of the two groups

and the positive expression of CD57 in PTC group and BTL group was compared to analyze the diagnostic efficacy of CD57 in PTC. All PTC patients underwent US-FNAB and FNA-Tg detection before surgery

and the efficacy of US-FNAB

US-FNAB combined with FNA-Tg in diagnosing postoperative lymph node metastasis in PTC patients was analyzed.

Results:

The positive expression rate of CD57 in PTC group (83.33%) was higher than that in BTL group (4.00%). The sensitivity

specificity and accuracy of PTC were 83.33%

96.00% and 89.09%

respectively. Pathological examination of 120 cervical lymph node metastasis in 50 cases. When FNA-Tg＞serum-Tg was the positive transfer index

the sensitivity

specificity and accuracy were 90.00%

95.89% and 95.83%

respectively. When FNA-Tg＞10 ng/mL was positive for metastasis

the sensitivity

specificity and accuracy were 88.89%

96.00% and 93.33%

respectively. The sensitivity

specificity and accuracy of US-FNAB combined with FNA-Tg in the diagnosis of lymph node metastasis (98.00%

100.00%

99.17%) werehigher than that of US-FNAB (60.00%

97.14%

97.14%)

and the specificity was higher than that of FNA-Tg (96.00%) (

P

＜0.05).

Conclusion:

US-FNAB combined with FNA-Tg and CD57 can assist the diagnosis of PTC and lymph node metastasis.