乳头状甲状腺癌NIS蛋白与糖酵解相关蛋白GLUT1及HK2表达关系的研究

殷唯; 李亚明

doi:10.19732/j.cnki.2096-6210.2020.05.007

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乳头状甲状腺癌NIS蛋白与糖酵解相关蛋白GLUT1及HK2表达关系的研究

论著 | 更新时间：2025-12-15

- 乳头状甲状腺癌NIS蛋白与糖酵解相关蛋白GLUT1及HK2表达关系的研究
- Study on the relationship between NIS protein expression and GLUT1, HK2 related to glycolysis in papillary thyroid carcinoma
- 肿瘤影像学 2020年29卷第5期页码：460-466
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- DOI：10.19732/j.cnki.2096-6210.2020.05.007
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- 网络出版：2020-10-28，
  
  纸质出版：2020-10-28
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殷唯,李亚明. 乳头状甲状腺癌NIS蛋白与糖酵解相关蛋白GLUT1及HK2表达关系的研究[J]. 肿瘤影像学, 2020, 29(5): 460-466 https://doi.

org/10.19732/j.cnki.2096-6210.2020.05.007
殷唯,李亚明. 乳头状甲状腺癌NIS蛋白与糖酵解相关蛋白GLUT1及HK2表达关系的研究[J]. 肿瘤影像学, 2020, 29(5): 460-466 https://doi. DOI： 10.19732/j.cnki.2096-6210.2020.05.007.

org/10.19732/j.cnki.2096-6210.2020.05.007 DOI：

摘要

目的：

研究乳头状甲状腺癌（papillary thyroid carcinoma，PTC）钠碘同向转运体（sodium iodide symporter，NIS）蛋白表达与糖酵解相关蛋白葡萄糖转运体1（glucose transporters 1，GLUT1）及己糖激酶2（hexokinase 2，HK2）的关系及临床意义。

方法：

采用免疫组织化学技术检测患者NIS、GLUT1及HK2蛋白在癌组织及正常组织中的表达情况。应用SPSS 25.0软件对结果进行统计学分析，

＜0.05为差异有统计学意义。

结果：

61例患者NIS、GLUT1和HK2蛋白表达在癌组织及正常组织中的差异有统计学意义（

=-3.251、6.594、2.801，

均＜0.05）。在癌组织中，HK2蛋白在NIS蛋白高/低表达组中的表达差异有统计学意义，且呈正相关（

=2.324，

＜0.05；

=0.404，

＜0.05）；GLUT1蛋白表达的差异无统计学意义，且无相关性（

=-1.020，

＞0.05；

=0.038，

＞0.05）。在正常组织中，HK2蛋白在NIS蛋白高低表达组中的表达差异有统计学意义，但无相关性（

=0.253，

＜0.05；

=0.246，

＞0.05）；GLUT1蛋白表达的差异无统计学意义，且无相关性（

=0.253，

＞0.05；

=-0.177，

＞0.05）。NIS蛋白表达情况在肿瘤大小分组中的差异有统计学意义（

=4.128，

＜0.05），而GLUT1和HK2蛋白表达的差异无统计学意义（

=0.015、0.236，

＞0.05）。NIS、GLUT1及HK2蛋白表达的差异在年龄分组、是否伴有淋巴结转移及肿瘤分期等方面差异均无统计学意义。

结论：

PTC中NIS蛋白与糖酵解相关蛋白GLUT1及HK2的差异表达，可作为解释

131

I全身扫描不显影而PET/CT显像存在摄取的这种反转现象的理论依据。

Abstract

Objective:

To study the relationship between sodium iodide symporter (NIS)

glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) expression in papillary thyroid carcinoma (PTC) and their clinical significance.

Methods:

Immunohistochemistry was used to detect the expression of NIS

GLUT1 and HK2 proteins in cancer and normal tissues

and analyzed the relationship between the expression of the three proteins and their clinical significance. SPSS 25.0 software was used for statistical analysis of the results

and

＜0.05 was considered statistically significant.

Results:

The expression of NIS

GLUT1 and HK2 proteins in the cancer and normal tissues of the 61 patients showed statistically significant differences (

=-3.251

6.594

2.801

＜0.05). In cancer tissues

HK2 protein expression was statistically significant in the high and low NIS protein expression group and NIS protein was positively correlated with HK2 (

=2.324

＜0.05;

=0.404

＜0.05). There was no statistical difference of expression of GLUT1 protein in the high and low NIS protein expression group and NIS protein had no correlation with GLUT1 (

=-1.020

＞0.05;

=0.038

＞0.05). In normal tissues

HK2 protein expression was also statistically significant in the high and low NIS protein expression group but NIS protein has no correlation with HK2 (

=0.253

＜0.05;

=0.246

＞0.05). There was no statistical difference of expression of GLUT1 in the high and low NIS protein expression group and NIS protein has no correlation with GLUT1 (

=0.253

＞0.05;

=-0.177

＞0.05). NIS protein expression in tumors of different volumes was statistically significant (

=4.128

＜0.05).Therewere no statistically significant difference on GLUT1 and HK2 protein expression in tumors of differen

t volumes (

=0.015

0.236;

＞0.05). The expression of NIS

GLUT1 and HK2 protein had no statistical significance in age group

lymph node metastasis and tumor stage.

Conclusion:

The relationship between the expression of NIS protein and the glycolytic related proteins GLUT1 and HK2 in PTC may serve as a theoretical basis for the reversal of PET/CT uptake in

131

I whole-body scan.

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