Objective:

To investigate the value of total tumor perfusion parameters in the diagnosis of benign and malignant solitary nodes in the lung with 320-row volume CT single and dual-input technique

and to explore the diagnostic threshold.

Methods:

A prospective perfusion scan was performed on the isolated lung lesions in Honghe Prefecture Third Peoples Hospital from Sep. 2016 to Oct. 2017. All data were post-processed by Vital workstations

all obtained under dual input mode (DI-CTP): bronchial artery blood flow (AF)

pulmonary blood flow (PF)

pulmonary perfusion index [PI; PI=PF/(AF+PF)

]

; under single input mode (SI-CTP): equivalent blood volume (E.BV)

blood flow extraction function (FE)

single-input arterial blood flow (S-AF). All data were statistically analyzed using SPSS 19.0 statistical software.

Results:

① There were significant differences in AF

PI

E.BV

FE and S-AF between benign and malignant lesions in the lung. ② The area under curve (AUC) of the receiver operatingcharacteristic (ROC) curve of the whole tumor perfusion parameters of benign and malignant lesions in the lung were: AF

0.771; E.BV

0.906; FE

0.772; S-AF

0.775; PI

0.889

and E.BV＞PI＞S-AF＞FE＞AF. The diagnostic threshold

sensitivity

specificity of E.BV were 5.00 mL/100 mL

0.909

0.857

respectively. The diagnostic threshold

sensitivity and specificity of PI were 43.24%

0.905

0.121

respectively. The diagnostic threshold

sensitivity and specificity of S-AF were 69.65 mL/(100 mLmin)

1.000

0.714

respectively. The diagnostic threshold

sensitivity and specificity of FE were 39.85 mL/(100 mLmin)

0.636

1.000

respectively. The diagnostic threshold

sensitivity and specificity of AF were 54.20 mL/(100 mLmin)

0.879

0.667

respectively. ③ Multiparameter combination

combined with morphological diagnosis positive prediction values reached 93.97%

negative prediction values reached 95.24%

diagnosis efficiency is significantly higher than

simple morphological diagnosis and single parameter diagnosis.

Conclusion:

The 320-volume CT total tumor perfusion parameters have practical application value in the identification of isolated benign and malignant lesions in the lung

and it is of great help. Among the multiple parameters

the diagnostic performance of PI

E.BV and FE is outstanding. Multi-parameter combination

combined with traditional morphological diagnosis

can achieve higher diagnostic compliance rates. The diagnostic boundary value of each parameter has yet to be explored

and it is urgent to unify the research standard.