Objective:

To explore the difference and correlation between the four molecular types of breast cancer

Luminal A

Luminal B

human epidermal growth factor receptor 2 (HER2) overexpression

triple-negative breast cancer (TNBC)

and digital breast tomosynthesis (DBT) image characteristics.

Methods:

A total of 209 patient

s with breast cancer confirmed by pathology in Guangdong Province Hospital for Women and Children Healthcare were collected. DBT examination and immunohistochemistry were performed before operation to analyze the size

shape

edge burr sign

microcalcification and axillary lymph node metastasis. According to the results of immunohistochemistry

patients were divided into Luminal A

Luminal B

HER2 overexpression type and TNBC

and the correlation between DBT imaging signs and molecular classification of breast cancer was analyzed.

Results:

Among 209 breast cancer patients

Luminal A

Luminal B

HER2 overexpression type

and TNBC patients were 41 cases (19.62%)

109 cases (52.15%)

28 cases (13.40%)

31 cases (14.83%)

respectively. Different molecular types of breast cancer and DBT imaging signs had statistically significant differences in tumor size

morphology

and microcalcification (

P

＜0.05). There were no statistically significant differences in patients age

burr signs

and axillary lymph node metastasis (

P

＞0.05).

Conclusion:

Luminal B is the most common. HER2 overexpression type is often accompanied by burr signs

microcalcifications and multiple irregularities. The TNBC has large lumps

regular morphology

and mostly no microcalcifications and burr signs. The imaging features of DBT can predict the molecular classification of breast cancer

and provide reliable imaging basis for the judgment of tumor biological behavior

prognosis evaluation and individualized treatment before clinical operation.