Objective:

To evaluate the value of

BRAF

V600E mutation in determining the invasiveness of papillary carcinoma of thyroid (PTC) and its related influencing factors.

Methods:

A total of 174 PTC patients who underwent ultrasound guided fine- needle aspiration cytology (FNAC) and

BRAF

V600E mu

tation detection before surgery were selected. All PTC patients were divided into mutation group 151 cases and no mutation group of 23 cases. The clinical pathological features and the ultrasonic characteristics between the two groups were compared

and single factor analyzed the correlation between observational indexes and

BRAF

V600E mutation

binary logistic regression analysis screened out risk factors closely related to

BRAF

V600E mutation.

Results:

There was no statistical difference in

BRAF

V600E mutation and clinicopathological features between the two groups (

P

＞0.05)

and there was a statistical difference in some ultrasonic features (nodule position

maximum diameter

calcification

and posterior attenuation) between them (

P

＜0.05). Only the calcification and location of cancer nodules were closely related to

BRAF

V600E (

P

＜0.05).

BRAF

V600E mutations were more likely to occur in the PTC nodules which were close to the anterior capsule and without calcification.

Conclusion:

BRAF

V600E mutation has no obvious correlation with PTC invasive characteristics

and it is closely related to calcification and location in ultrasonic features. When the suspected PTC nodule has no calcification or is close to the anterior capsule

BRAF

V600E mutation is likely more freguent.