Objective:

To investigate the treatment of secondary hyperparathyroidism (SHPT) with ultrasound-guided percutaneous radiofrequency ablation (RFA).

Methods:

A total of 36 SHPT patients were selected as the study subjects

of which 16 were treated with ultrasound guided RFA

20 underwent traditional parathyroidectomy (PTX). The clinical data

lab

oratory examination (postoperative 1 d

1 week

1 month

3 months

6 months and 1 year of parathyroid hormone (PTH)

calcium (Ca)

blood phosphorus (P) and alkaline phosphatase (ALP) levels were analyzed. The improvement of clinical symptoms and complications were observed

and the safety and efficacy of treatment were evaluated.

Results:

After 1 d

1 week

1 month

3 months

6 months and 1 year

the levels of PTH

Ca and P in 2 groups were significantly decreased (

P

＜0.05)

and the ALP levels were no significant difference before and after operation (

P

＞0.05). There was no significant difference in postoperative laboratory indexes between 2 groups (

P

＞0.05). Postoperative muscle weakness

bone pain

skin pruritus and neurological symptoms were significantly improved in both groups. There was 1 case of hoarseness combined with hypocalcemia and 1 case of postoperative intermuscular hematoma after RFA;1 case of hypocalcemia and 1 case of hoarseness after PTX. There were no significant differences between 2 groups (

P

＞0.05).

Conclusion:

The efficacy of ultrasound-guided RFA in the treatment of SHPT is similar to PTX

which can significantly improve the patients clinical symptoms and quality of life.