Objective:

To study the correlation between estrogen receptor (ER) expression status and high frequency ultrasound and shear wave elastography (SWE) characteristics in human epidermal growth factor 2 (HER2) positive breast cancer patients.

Method:

A total of 136 patients were selected from Tang Shan peoples hospital in March 2019 to December 2020 in breast surgery

who had definite pathology and HER2 positive expression

including 77 patients with negative ER (group Ⅰ) and 59 patients with positive ER (group Ⅱ). High frequency ultrasound and SWE were performed to obtain the corresponding variables. The expression of each variable and the differences among the molecular typing were compared respectively. Finally

the above variables with differences were established Logistic regression model to evaluate the diagnostic value of each variable. Using the immunohistochemical results as the gold standard

the receiver operating characteristic (ROC) curve was used to analyze and compare the qualitative and quantitative indicators.

Results:

High frequency ultrasound: group Ⅰ are more likely to appear axillary lymph node metastasis than group Ⅱ (

P

＜0.05). SWE: group Ⅰ had higher maximum (

E

max

)

mean (

E

mean

)

minimum (

E

min

) value of Youngs modulus than group Ⅱ (

P

＜0.05). Logistic regression showed that lymph node metastasis (OR=0.553

P

=0.004) and

E

max

(OR=0.877

P

=0.000) were independent influencing factors for the results of immunohistochemistry. The area under the curve oflymph node metastasis ndicators was 0.602

P

=0.042

95% CI 0.506-0.698. The diagnostic sensitivity and specificity were 59.3% and 61.0%. The area under the

E

max

index curve was 0.910

P

=0.000

95% CI 0.861-0.959

diagnostic sensitivity was 96.6%

specificity was 79.2%

and cut-off value

was 124.335.

Conclusion:

When breast cancer patients expressed positive HER2

their incidence of axillary lymph node metastasis and Youngs modulus value were significantly different under different ER expression status

Both lymph node metastasis and

E

max

value were independent influencing factors

among which

E

max

value had the best diagnostic efficacy

which will play an important guiding role in the selection of clinical treatment plan.