<sup>68</sup> Ga-DOTATATE PET/CT与 <sup>18</sup> F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究

唐文鑫; 王琦新; 杨松松; 刘汉香; 彭登赛; 陈跃

doi:10.19732/j.cnki.2096-6210.2022.03.003

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⁶⁸ Ga-DOTATATE PET/CT与 ¹⁸ F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究

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- ⁶⁸ Ga-DOTATATE PET/CT与 ¹⁸ F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究
- A comparative study of ⁶⁸Ga-DOTATATE PET/CT and ¹8 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm
- 肿瘤影像学 2022年31卷第3期页码：230-235
- 作者机构：
  
  1. 四川省院士（专家）工作站,四川,泸州,646000
  2. 西南医科大学附属医院核医学科,四川,泸州,646000
  3. 四川省核医学与分子影像重点实验室,四川,泸州,646000
- 作者简介：
- 基金信息：
  
  国家自然科学基金联合基金项目（U20A20384）;泸州市人民政府西南医科大学科技战略合作项目（2021LZXNYD-P03）
- DOI：10.19732/j.cnki.2096-6210.2022.03.003
  中图分类号：
- 网络出版：2022-06-28，
  
  纸质出版：2022-06-28
- 稿件说明：
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唐文鑫,王琦新,杨松松,等. ⁶⁸ Ga-DOTATATE PET/CT与 ¹⁸ F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究[J]. 肿瘤影像学, 2022, 31(3): 230-235 https://doi.

org/10.19732/j.cnki.2096-6210.2022.03.003
唐文鑫,王琦新,杨松松,等. ⁶⁸ Ga-DOTATATE PET/CT与 ¹⁸ F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究[J]. 肿瘤影像学, 2022, 31(3): 230-235 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.03.003.

org/10.19732/j.cnki.2096-6210.2022.03.003 DOI：

摘要

目的：

对比评估 68 Ga-DOTATATE正电子发射体层成像（positron emission tomography，PET）/计算机体层成像（computed tomography，CT）与

F-FDG PET/CT对分化良好和分化不良胃肠胰神经内分泌肿瘤（gastroenteropancreatic neuroendocrine neoplasm，GEP-NEN）的诊断效能。

方法：

回顾并分析2018年12月2022年1月于西南医科大学附属医院经病理学检查确诊为GEP-NEN的71例患者（男性32例，女性39例，中位年龄54岁）的临床病理学资料及

Ga-DOTATATE、

F-FDG PET/CT显像结果。将患者分为分化良好组及分化不良组，对上述两组患者的

Ga-DOTATATE PET/CT及

F-FDG PET/CT显像阳性率、病灶（原发及转移性）显示数量进行统计对比。

结果：

分化良好组

Ga-DOTATATE PET/CT及

F-FDG PET/CT显像阳性率分别为80.6%及48.4%，差异有统计学意义（

=14.091，

＜0.05），病灶显示数量差异无统计学意义（

=2.116，

=0.169）。分化不良组

Ga-DOTATATE PET/CT及

F-FDG PET/CT显像阳性率分别为55.6%及100.0%，差异无统计学意义（

=0.082），病灶显示数量差异无统计学意义（

=1.0）。对于本研究中所有GEP-NEN患者，

Ga-DOTATATE PET/CT显像阳性率为77.5%（55/71），

F-FDG PET/CT显像阳性率为54.9%（39/71），

8 Ga-DO

TATATE PET/CT显像阳性率更高。结论：对于不同分化程度的GEP-NEN，

F-FDG PET/CT及

Ga-DOTATATE PET/CT显像效能不同，但发挥着互补的作用。不同分化程度的NEN患者均可有生长抑素受体（somatostatin receptor，SSTR）高表达，表明其有望从肽受体放射性核素疗法（peptide radionuclide receptor therapy，PRRT）中获益。

Abstract

Objective:

To investigate the diagnostic efficiency of

Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) in comparison to

8 F-FDG PET/CT in patients with well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN).

Methods:

From December 2018 to January 2022

71 patients (32 males

39 females

median age 54) with GEP-NEN proved by pathology in The Affiliated Hospital of Southwest Medical University who underwent both

Ga-DOTATATE PET/CT and

F-FDG PET/CT scan were retrospectively analyzed. The patients were divided into two groups

well-differentiated group and poorly differentiated group. The positive rate of

Ga-DOTATATE PET/CT and

F-FDG PET/CT scan in the above two groups of patients

and the number of primary and metastatic lesions were evaluated.

Results:

In the well-differentiated group

the positive rates of

Ga-DOTATATE and

F-FDG scan were 80.6% and 48.4%

which reached statistical significance (

=14.091

0.05)

and there was no significant difference in the number of detected lesions between

Ga-DOTATATE and

F-FDG PET/CT (

=2.116

=0.169). In the poorly differentiated group，the positive rate of

Ga-DOTATATE and

F-FDG scan were 55.6% and 100.0%

which did not reach statistical significance (

=0.082)

and there was no significant difference in the number of detected lesions between

Ga-DOTATATE and

F-FDG PET/CT (

.0). In both well-differentiated and poorly differentiated group

Ga-DOTATATE PET/CT did not significantly differ from

F-FDG PET/CT in identifying primary and distant lesions. In all patients with GEP-NEN in this study

Ga-DOTATATE PET/CT were positive in 77.5% （55/71）patients

F-FDG PET/CT were positive in 54.9%（39/71）patients

which indicate the positive rate of

Ga-DOTATATE PET/CT is higher in comparison to that in

F-FDG PET/CT.

Conclusion:

For GEP-NEN with different degrees of differentiation

F-FDG PET/CT and

Ga-DOTATATE PET/CT performances are different

but they play complementary roles. NEN patients with different degrees of differentiation can have high somatostatin receptor (SSTR) expression

indicating that they are expected to benefit from peptide radionuclide receptor therapy (PRRT).

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A comparative study of 68 Ga-DOTATATE PET/CT and 18 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm

DOI：10.19732/j.cnki.2096-6210.2022.03.003

摘要

Abstract

关键词

Keywords

references

⁶⁸ Ga-DOTATATE PET/CT与 ¹⁸ F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究

A comparative study of ⁶⁸Ga-DOTATATE PET/CT and ¹8 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm