Objective:

To explore the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters combined with serum carbohydrate antigen (CA) 19-9 and CA724 levels in evaluating the differentiation degree of rectal cancer.

Methods:

A total of 129 patients with rectal cancer diagnosed by pathology in Changzhi peoples Hospital from May 2018 to November 2020 were selected as the research objects. DCE-MRI examination and serum CA19-9

CA724 levels were detected before treatment. DCE-MRI parameters and serum CA19-9 and CA724 levels in patients with different tumor differentiation degrees (high differentiation

medium/low differentiation) were compared. Receiver operating characteristic (ROC) curve was used to analyze the value of DCE-MRI parameters and serum CA19-9 and CA724 levels in evaluating the differentiation degree of rectal cancer patients.

Results:

Volume transport constant (K

trans

)

intensive area under the cure (iAUC)

volume fraction of extracellular space (V

e

) and serum CA19-9

CA724 levels of high/medium differentiation differentiated patients were lower than those of undifferentiated/poorly differentiated patients (

P

＜0.05). Mean apparent diffusion coefficient (ADC

mean

) value of high/medium patients was higherthan that of undifferentiated/poorly differentiated patients (

P

＜0.05). The sensitivity

specificity and AUC of DCE-MRI were 81.25%

82.47% and 0.792 respectively. The sensitivity and AUC were higher than those of single prediction (

P

＜0.05). There was no significant difference between the specificity and single prediction (

P

＞0.05). The sensitivity

specificity and AUC of DCE-MRI parameters combined with serum CA19-9 and CA724 levels in evaluating the differentiation degree of rectal

cancer patients were 96.88%

85.57% and 0.889

respectively. The sensitivity and AUC of combined prediction were higher than those of single prediction (

P

＜0.01)

and there was no significant difference between combined prediction and single prediction (

P

＞0.05).

Conclusion:

In DCE-MRI parameters

K

trans

iAUC

V

e

and serum CA19-9

CA724 levels increase with the decrease of rectal cancer differentiation degree

ADC

mean

value decreases with the decrease of rectal cancer differentiation degree

which can be used as one of the indicators for clinical evaluation of rectal cancer differentiation degree

and the above indicators play a better role in joint evaluation. The value is more obvious

which has important guiding significance for clinical condition judgment and treatment choice.