Objective:

To explore the ultrasound

mammography and magnehy resonance imaging (MRI) features of invasive breast carcinoma of no special type (IBC-NST) with medullary pattern

as well as the corresponding pathological features.

Methods:

Imaging and clinical pathological findings of totally 21 cases of IBC-NST with medul

lary pattern proved by postoperative pathology were analyzed retrospectively.

Results:

There were 21 lesions in 21 IBC-NST with medullary pattern patients. The 15 lesions were located in the outer upper quadrant

20 lesions were histopathologic grade Ⅲ

and 12 lesions were triple negative. Ultrasound findings showed irregular shape (61.9%)

smooth margin or moderate smooth margin (57.1%)

calcification (42.9%)

enhanced echo behind the lesions (28.6%). Nineteen lesions had abundant blood apply

and 16 of them had high resistance index. Ultrasound elastography was performed in 10 cases

and the elasticity in 7 cases was soft to medium. Mammography was performed in 10 cases

and 2 cases were classified into Breast Imaging Reporting and Data System (BI-RADS) 3. Six cases underwent MRI examination

all of which showed heterogeneous enhancement and limited diffusion. The time intensity curve (TIC) of 5 lesions was type Ⅱ.

Conclusion:

IBC-NST with medullary pattern morphologically showed benign imaging features on ultrasound and mammography. However

the blood apply in the lesion was abundant and the resistance index was high on ultrasound. MRI findings of IBC-NST with medullary pattern were basically consistent with common invasive carcinoma. The comprehensive evaluationof multiple imaging is of certain value for the diagnosis and differential diagnosis of IBC-NST with medullary pattern

and the combination of clinical features is helpful to further reduce the misdiagnosis rate.