Objective:

To investigate the influences of particulate matter 2.5 (PM2.5)

ambient temperature

ultraviolet radiation and green space on thyroid cancer in different regions of China.

Methods:

2015 thyroid incidence data from 388 counties were collected from 2018 China Cancer Registry. Datasets of PM2.5 concentration

ambient temperature

sunshine duration and normalized difference vegetation index were downloaded from public databases. Geodetector was applied to analyze the ef

fect of selected factors by explanatory power (q).

Results:

The q of PM2.5

ambient temperature

ultraviolet radiation and green space on male were 0.039

0.004

0.041

0.088

respectively; which were 0.084

0.109

0.091

0.049

respectively on female. Enhanced effects were found when two factors interacted. Spatially

higher thyroid cancer morbidity was observed in regions with severe ambient pollution

cold climate

strong ultraviolet radiation and insufficient green space.

Conclusion:

Exposure to air pollution

cold climate

strong ultraviolet radiation and lack of green space might be the risk factors of thyroid cancer. These findings may help guide cancer prevention and warrant further investigations.