Objective:

To compare the differences of

18

F-FDG positron emission tomography (PET) /computed tomography (CT) metabolic parameters between automatic segmentation software and manual measurement

and to investigate the feasibility of applying automatic segmentation software to diffuse large B-cell lymphoma (DLB

CL).

Methods:

52 patients who in Huadong Hospital of Fudan University underwent

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F-FDG PET/CT were selected. Metabolic parameters and number of lesions were measured by both methods

and processing time was recorded. Spearman rank correlation analysis and Wilcoxon rank test were used to compare the correlation and difference between metabolic parameters obtained by the two methods.

Results:

The maximum standard uptake value (SUV

max

) and SUV

peak

measured by the two outlining methods were identical

SUV

mean

metabolic tumor volume (MTV)

and total lesion glycolysis (TLG) were highly correlated and no statistical difference was observed

and the lesion detection ability and efficiency of the auto software were higher than manual measurement.

Conclusion:

The metabolic parameters measured by

18

F-FDG PET/CT automatic segmentation software has good stability and reliability

and can be applied to DLBCL patients.