Objective:

To investigate the influencing factors of radioiodine therapy in papillary carcinoma of the th

yroid (PTC) patients with postoperative residual lymph node metastases for providing more reference for subsequent individualized treatment.

Methods:

A total of 151 PTC patients with postoperative residual lymph node metastases before

131

I treatment were retrospectively chosen in the period from January 2011 to January 2016 in 3201 Hospital. All patients were grouped according to

131

I treatment effect and included best response group (92 cases) and non-optimum response group (59 cases). The clinical characteristics of 2 groups were compared and multivariate logistic regression model was used to evaluate the independent influencing factors of

131

I treatment effect. Receiver operating characteristic (ROC) curve was drawn to evaluate the clinical efficiency of above independent influencing factors in predicting for

131

I treatment effect.

Results:

The levels of thyroglobulin (Tg) level in thyroid-stimulating hormone (TSH) excited state and the minimal length of metastatic lymph nodes of best response group were significantly less than non-optimum response group（

P

＜0.05）. Logistic regression model multivariate analysis showed that Tg level in the excited state of TSH

the smallest metastatic lymph node and American Thyroid Association (ATA) risk stratification were independent influencing factors for clinical efficacy of

131

I treatment（

P

＜0.05）. ROC curve analysis showed that Tg level in TSH excited state

minimal metastatic lymph node and ATA risk stratification could be used to predict clinical efficacy of

131

I treatment

and combination of above three hadthe best prediction efficiency

and the predictive efficiency of Tg level in TSH excited state was better than other two.

Conclusion:

The clinical efficacy of radioiodine therapy is not only related to the smallest of metastatic lymph nodes and the ATA risk stratification

but also independently affected by the Tg level in the e

xcited state of TSH in PTC patients with postoperative residual lymph node metastasis. And the level of Tg can be used to predict the clinical efficiency of radioiodine therapy and the combination with other factors has better predictive efficiency.