Objective:

To investigate the efficacy and prognosis of computed tomography (CT)-guided radiofrequency ablation for elderly patients with non-small cell lung cancer (NSCLC) who cannot be treated with surgery.

Methods:

From January 2010 to January 2014

191 elderly patients with NSCLC who could not be treated surgically were selected as the study subjects. To observe the eff

icacy

safety and prognosis of radiofrequency ablation in the treatment of elderly NSCLC.

Results:

191 elderly patients with NSCLC underwent CT-guided radiofrequency ablation successfully. The total effective rate was 47.12%. The incidence of complications was 49.74% in 191 patients

and there was no death. The 1

3

5-year overall survival rates of 191 patients with NSCLC were 94.76%

70.68% and 37.70%

while the 1

3 and 5-year disease-free survival rates were 84.82%

62.83% and 28.27%. Cox univariate and multivariate analysis showed that tumor diameter

TNM stage

lymph node metastasis

molecular targeted therapy and lymphovascular invasion (LVI) were closely related to the overall survival of elderly patients with NSCLC. Tumor diameter

lymph node metastasis and LVI were closely related to the disease-free survival of elderly patients with NSCLC.

Conclusion:

CT- guided radiofrequency ablation might have a certain curative effect on inoperable elderly patients with NSCLC

and the safety isacceptable. Tumor diameter

TNM stage

lymph node metastasis

molecular targeted therapy

and LVI may affect the prognosis of patients receiving radiofrequency ablation.