Objective:

To analyze the value of fast spin-echo diffusion-weighted imaging (TSE-DWI) in the evaluation of focal activity in children with intraocular simul

taneous unilateral retinoblastoma (RB).

Methods:

The magnetic resonance imaging (MRI) data and relevant clinical data of 180 children with intraocular simultaneous unilateral RB who were clinically diagnosed and treated in the Affiliated Childrens Hospital of Shandong University from May 2014 to July 2018 and 53 communal healthy volunteers (control group) were collected. All cases were performed MRI routine sequence

TSE-DWI and dynamic contrast-enhanced MRI (DCE-MRI)

and were examined once before treatment

after treatment and in stable period

the control group was scanned once. The changes of apparent diffusion coefficient (ADC) and signal intensity enhancement ratio (△SI) in the active and stable stage of the intraocular lesions and the control group were compared

and their effectiveness in evaluating whether the lesions were active or no.

Results:

The TSE-DWI of lesions before treatment showed high signal

the corresponding ADC image showed low signal

and the enhanced scanning showed enhancement with different degrees. After treatment

the lesion volume decreased

the DWI signal decreased

the ADC image signal increased，no or medium enhancement. The differences of ADC and △SI in active phase

stable phase and control group were statistically significant (

P

＜0.001). When △SI=1.14%

the sensitivity

specificity and accuracy of identifying whether the lesion was active were 75.91%

82.31%

and 87.56% respectively. When ADC=1.1710

-3

/mm

2

the sensitivity

specificity and accuracy of identifying whether the lesion was active were 95.72%

87.23%and 93.76% respectively. The energy efficiency of the two method to distinguish whether the lesion was active similarly.

Conclusion:

In assessing whether the lesion is active or not

the value of TSE-DWI was similar to the DCE-MRI

but TSE-DWI has the advantage.