Objective:

To analyze the imaging features of granular cell tumor of the breast (GCT-B)

as well as clinicopathological characteristics

in order to improve the understanding and the ability of differential diagnosis of GCB-T for clinicians.

Methods:

Imaging findings on digital mammograph (DM) and magnetic resonance imaging (MRI)

clinical presentations

pathological and immunohistochemical examinations of 11 cas

es of GCT-B confirmed by pathology in Fudan University Shanghai Cancer Center from March 2017 to October 2022 were retrospectively analyzed

including 10 cases of DM

6 cases of MRI.

Results:

In the 11 GCT-B cases

1 was male and 10 were female

the age of onset ranged from 20 to 66 years

with a median age of 35 years

more frequently in were premenopausal women (8 cases)

mostly found by accident (10 cases). The lesions were all solitary small mass

with a diameter range from 14 to 17 mm

mostly located in the upper quadrants of the breast (10 cases). The lesions have different shapes on DM

5 cases with spiculate boundary

none with calcification. On MRI plain scan

the signal of the tumor is variable. After dynamic enhancement

all mases showed rapid enhanced in early-phase

with persistent or enhanced enhancement in delay-phase. 11 cases with S-100 positivity

10 cases with SOX-10 positivity

8 cases with CD68 positivity

Ki-67 proliferative indexs were less than 10%. There was no recurrence during 4 to 70 month follow-up.

Conclusion:

GCT-B is a rare tumor of the breast

which usually occurs in the upper part of the breast and was more common in premenopausal women. GCT-B presents as solitary mass on DM

usually without calcification

and shows rapid mass-like enhancement in early phase on dynamic enhanced MRI

which are of significance for clinical diagnosis.