Objective:

To investigate the relationship between clinicopathologic and ultrasonographic features of Luminal A breast cancer and axillary lymph node metastasis.

Methods:

In this study

a total of 301 female patients with Luminal A breast cancer confirmed by pathology in Nanjing Medical University First Hospital from January 2016 to October 2022 were selected

of whom 82 were in

the lymph node metastasis group and 219 were in the non-metastasis group. The correlation between clinicopathological and ultrasonographic features of Luminal A breast cancer and axillary lymph node metastasis was determined by univariate and logistic regression analyses.

Results:

The results of univariate analysis showed statistically significant differences in size

shape

margin of tumor and short diameter

long diameter/short diameter (L/S＜2)

loss of lymphatic portal structures

cortical thickness (＞3 mm)

type of blood supply (non-lymphoid portal type) and vascularity of lymph node (abundant) between the two groups

which correlated with lymph node metastasis (

P

＜0.05). Logistic regression analysis showed that size of the tumor (OR=1.842

P

=0.016)

cortical thickness of lymph node (OR=2.649

P

=0.036)

L/S (OR=0.354

P

=0.007) and vascularity of lymph node (OR=2.255

P

=0.039) were independent risk factors for axillary lymph node metastasis in Luminal A breast cancer.

Conclusion:

Clinicopathological and ultrasonographic features of patients with Luminal A breast cancer can predict axillary lymph node metastasis and provide a reference for clinicians in the treatment of Luminal A breast cancer.